
Alcohol Dependence To determine if topiramate is a safe and effective treatment for alcohol dependence, researchers conducted a 14-week trial of 371 men and women aged 18 to 65 years diagnosed with alcohol dependence. In this double-blind, randomized, placebo-controlled experiment, subjects were randomly given either 300 milligrams (mg) of topiramate (183 subjects) or a placebo (188 subjects) daily, along with a weekly compliance enhancement intervention. The variable used to determine the effectiveness of the treatment was self-reported percentage of heavy drinking days. Results indicated that topiramate was more effective than placebo at reducing the percentage of heavy drinking days. The researchers concluded that topiramate is a promising treatment for alcohol dependence.
Source: Bankole A. Johnson, Norman Rosenthal, et al. “Topiramate for Treating Alcohol Dependence: A Randomized Controlled Trial,” Journal of the American Medical Association, 298(14): 1641–1651, 2007
- a. What does it mean for the experiment to be placebo-controlled?
- b. What does it mean for the experiment to be double-blind? Why do you think it is necessary for the experiment to be double-blind?
- c. What does it mean for the experiment to be randomized?
- d. What is the population for which this study applies? What is the sample?
- e. What are the treatments?
- f. What is the response variable?

Want to see the full answer?
Check out a sample textbook solution
Chapter 1 Solutions
Fundamentals of Statistics, Books a la Carte Edition Plus MyLab Statistics with Pearson eText -- Access Card Package (5th Edition)
- Harvard University California Institute of Technology Massachusetts Institute of Technology Stanford University Princeton University University of Cambridge University of Oxford University of California, Berkeley Imperial College London Yale University University of California, Los Angeles University of Chicago Johns Hopkins University Cornell University ETH Zurich University of Michigan University of Toronto Columbia University University of Pennsylvania Carnegie Mellon University University of Hong Kong University College London University of Washington Duke University Northwestern University University of Tokyo Georgia Institute of Technology Pohang University of Science and Technology University of California, Santa Barbara University of British Columbia University of North Carolina at Chapel Hill University of California, San Diego University of Illinois at Urbana-Champaign National University of Singapore McGill…arrow_forwardName Harvard University California Institute of Technology Massachusetts Institute of Technology Stanford University Princeton University University of Cambridge University of Oxford University of California, Berkeley Imperial College London Yale University University of California, Los Angeles University of Chicago Johns Hopkins University Cornell University ETH Zurich University of Michigan University of Toronto Columbia University University of Pennsylvania Carnegie Mellon University University of Hong Kong University College London University of Washington Duke University Northwestern University University of Tokyo Georgia Institute of Technology Pohang University of Science and Technology University of California, Santa Barbara University of British Columbia University of North Carolina at Chapel Hill University of California, San Diego University of Illinois at Urbana-Champaign National University of Singapore…arrow_forwardA company found that the daily sales revenue of its flagship product follows a normal distribution with a mean of $4500 and a standard deviation of $450. The company defines a "high-sales day" that is, any day with sales exceeding $4800. please provide a step by step on how to get the answers in excel Q: What percentage of days can the company expect to have "high-sales days" or sales greater than $4800? Q: What is the sales revenue threshold for the bottom 10% of days? (please note that 10% refers to the probability/area under bell curve towards the lower tail of bell curve) Provide answers in the yellow cellsarrow_forward
- Find the critical value for a left-tailed test using the F distribution with a 0.025, degrees of freedom in the numerator=12, and degrees of freedom in the denominator = 50. A portion of the table of critical values of the F-distribution is provided. Click the icon to view the partial table of critical values of the F-distribution. What is the critical value? (Round to two decimal places as needed.)arrow_forwardA retail store manager claims that the average daily sales of the store are $1,500. You aim to test whether the actual average daily sales differ significantly from this claimed value. You can provide your answer by inserting a text box and the answer must include: Null hypothesis, Alternative hypothesis, Show answer (output table/summary table), and Conclusion based on the P value. Showing the calculation is a must. If calculation is missing,so please provide a step by step on the answers Numerical answers in the yellow cellsarrow_forwardShow all workarrow_forward
- Glencoe Algebra 1, Student Edition, 9780079039897...AlgebraISBN:9780079039897Author:CarterPublisher:McGraw HillCollege Algebra (MindTap Course List)AlgebraISBN:9781305652231Author:R. David Gustafson, Jeff HughesPublisher:Cengage Learning
- Holt Mcdougal Larson Pre-algebra: Student Edition...AlgebraISBN:9780547587776Author:HOLT MCDOUGALPublisher:HOLT MCDOUGAL



