Essential Cell Biology
Essential Cell Biology
4th Edition
ISBN: 9780815344544
Author: Keith Roberts, Karen Hopkin, Alexander D Johnson, Martin Raff, Dennis Bray, Bruce Alberts, Julian Lewis, Peter Walter
Publisher: TAYLOR
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Chapter 16, Problem 7Q
Summary Introduction

To explain: The reason why cells have evolved intracellular Ca2+ stores for signaling in spite of the availability of extracellular Ca2+.

Concept introduction: The phospholyase C is activated on the plasma membrane by the GPCR. The Phospholyase C (PL C) then cleaves the inositol phospholipid on the plasma membrane, which is the phosphatidyl inositol. PL C cleaves the phosphatidyl inositol into inositol triphosphate and diacyl glycerol which are secondary messengers. Inositol triphosphate in the cytosol opens the calcium channels on the surface of the endoplasmic reticulum.

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