Microbiology: A Laboratory Manual (11th Edition)
Microbiology: A Laboratory Manual (11th Edition)
11th Edition
ISBN: 9780134098630
Author: James G. Cappuccino, Chad T. Welsh
Publisher: PEARSON
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Chapter 16, Problem 72E.2RQ
Summary Introduction

To define: The blood test for syphilis was reactive in a 20-year-old college student. The student was indicated as a virgin and had never received any blood transfusion. The result of the repeat RPR diagnostic test was positive, however, the result of the TPI test was negative. Explain the contradictory results.

Introduction: Syphilis is caused by Treponema pallidum. The major symptoms of syphilis are small lesion at the initial stage, skin and mucous membrane rashes, sore at the infected site, gummas, mild fever, malaise, loss of hair, cardiovascular, and nerve damage. It can be diagnosed by various serological tests, such as venereal disease research laboratory (VDRL) test, rapid plasma reagin (RPR) test, and fluorescent treponemalantibody-absorption (FTA-ABS) test. Benzathine penicillin is used to treat syphilis.

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Serology 101: Testing for IgG and IgM antibodies; Author: Beckman Coulter Dx;https://www.youtube.com/watch?v=LtqKB-qpJrs;License: Standard youtube license