ANATOMY+PHYSIOLOGY >CUSTOM<
9th Edition
ISBN: 2818440061721
Author: SALADIN
Publisher: MCG/CREATE
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 16, Problem 5TYC
Summary Introduction
Summary:
Drugs block the receptors for substance P, a neurotransmitter.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 16 Solutions
ANATOMY+PHYSIOLOGY >CUSTOM<
Ch. 16.1 - Not every sensory receptor is a sense organ....Ch. 16.1 - What does it mean to say sense organs are...Ch. 16.1 - Prob. 3BYGOCh. 16.1 - What is meant by the modality of a stimulus? Give...Ch. 16.1 - Three schemes of receptor classification were...Ch. 16.1 - Nociceptors are tonic rather than phasic...Ch. 16.1 - The definition of receptor and the range of...Ch. 16.1 - Prob. 2AYLOCh. 16.1 - Prob. 3AYLOCh. 16.1 - Prob. 4AYLO
Ch. 16.1 - Prob. 5AYLOCh. 16.1 - Prob. 6AYLOCh. 16.1 - Prob. 7AYLOCh. 16.2 - What stimulus modalities are detected by free...Ch. 16.2 - Prob. 8BYGOCh. 16.2 - Where do most second-order somatosensory neurons...Ch. 16.2 - Explain the phenomenon of referred pain in terms...Ch. 16.2 - Explain the roles of bradykinin, substance P, and...Ch. 16.2 - Prob. 12BYGOCh. 16.2 - Three Types of unencapsulated sensory nerve...Ch. 16.2 - Six types of encapsulated nerve endings and how...Ch. 16.2 - The main routes for somatosensory signals from the...Ch. 16.2 - Definitions of pain and nociceptorCh. 16.2 - Differences between fast pain and slow painCh. 16.2 - Differences between somatic and visceral pain, and...Ch. 16.2 - Several chemicals released by injured tissues that...Ch. 16.2 - The general three-neuron pathway typically taken...Ch. 16.2 - Pain pathways from receptors in the head to the...Ch. 16.2 - Pain pathways from the lower body to the cerebral...Ch. 16.2 - Prob. 11AYLOCh. 16.2 - Referred pain and its anatomical basisCh. 16.2 - Prob. 13AYLOCh. 16.2 - Prob. 14AYLOCh. 16.3 - Prob. 13BYGOCh. 16.3 - Prob. 14BYGOCh. 16.3 - Prob. 15BYGOCh. 16.3 - Prob. 16BYGOCh. 16.3 - Prob. 17BYGOCh. 16.3 - Prob. 1AYLOCh. 16.3 - Types, locations, and functions of lingual...Ch. 16.3 - Five primary taste sensations, and sensations...Ch. 16.3 - Prob. 4AYLOCh. 16.3 - Prob. 5AYLOCh. 16.3 - Prob. 6AYLOCh. 16.3 - How odor molecules excite olfactory cellsCh. 16.3 - Prob. 8AYLOCh. 16.3 - Prob. 9AYLOCh. 16.3 - Prob. 10AYLOCh. 16.4 - Prob. 18BYGOCh. 16.4 - Prob. 19BYGOCh. 16.4 - Prob. 20BYGOCh. 16.4 - Prob. 21BYGOCh. 16.4 - Prob. 22BYGOCh. 16.4 - Why can't we see wavelengths of 350 nm or 750 nm?Ch. 16.4 - Prob. 1AYLOCh. 16.4 - Prob. 2AYLOCh. 16.4 - Prob. 3AYLOCh. 16.4 - Prob. 4AYLOCh. 16.4 - Prob. 5AYLOCh. 16.4 - Prob. 6AYLOCh. 16.4 - The bony and membranous labyrinths of the inner...Ch. 16.4 - Prob. 8AYLOCh. 16.4 - Prob. 9AYLOCh. 16.4 - Prob. 10AYLOCh. 16.4 - Prob. 11AYLOCh. 16.4 - Prob. 12AYLOCh. 16.4 - Prob. 13AYLOCh. 16.4 - Prob. 14AYLOCh. 16.4 - The pathway from cochlear nerve to auditory...Ch. 16.4 - Prob. 16AYLOCh. 16.4 - Prob. 17AYLOCh. 16.4 - Prob. 18AYLOCh. 16.4 - Prob. 19AYLOCh. 16.4 - Prob. 20AYLOCh. 16.4 - Prob. 21AYLOCh. 16.4 - The path taken by signals in the vestibular nerve...Ch. 16.4 - Prob. 23AYLOCh. 16.5 - Prob. 24BYGOCh. 16.5 - Prob. 25BYGOCh. 16.5 - Prob. 26BYGOCh. 16.5 - Prob. 27BYGOCh. 16.5 - Prob. 28BYGOCh. 16.5 - Prob. 1AYLOCh. 16.5 - Six extrinsic eye muscles, their anatomy, the eye...Ch. 16.5 - Prob. 3AYLOCh. 16.5 - Prob. 4AYLOCh. 16.5 - Prob. 5AYLOCh. 16.5 - Prob. 6AYLOCh. 16.5 - Prob. 7AYLOCh. 16.5 - General structure of the retina: its two points of...Ch. 16.5 - Prob. 9AYLOCh. 16.5 - Prob. 10AYLOCh. 16.5 - Principles of refraction; points at which...Ch. 16.5 - The difference between enmetropia and lite near...Ch. 16.5 - Histological layers and cell types of the retina....Ch. 16.5 - The structures of rods and cones; where visual...Ch. 16.5 - Differences in rod and cone functionCh. 16.5 - Prob. 16AYLOCh. 16.5 - Prob. 17AYLOCh. 16.5 - Why a single retinal receptor system cannot...Ch. 16.5 - Difference between S, M, and L cones; how neural...Ch. 16.5 - Prob. 20AYLOCh. 16.5 - Prob. 21AYLOCh. 16.5 - Hemidecussation, where it occurs, and how it...Ch. 16.5 - Prob. 23AYLOCh. 16 - Hot and cold stimuli are detected by a. free nerve...Ch. 16 - _____is a neurotransmitter that transmits pain...Ch. 16 - Prob. 3TYRCh. 16 - Prob. 4TYRCh. 16 - Prob. 5TYRCh. 16 - Prob. 6TYRCh. 16 - Prob. 7TYRCh. 16 - Prob. 8TYRCh. 16 - The retina receives its oxygen supply from a. the...Ch. 16 - Prob. 10TYRCh. 16 - The most finely detailed vision occurs when an...Ch. 16 - Prob. 12TYRCh. 16 - Prob. 13TYRCh. 16 - Prob. 14TYRCh. 16 - Three rows of________in the cochlea have V-shaped...Ch. 16 - The ______ is a tiny bone that vibrates in the...Ch. 16 - The _____ of the midbrain receives auditory input...Ch. 16 - Prob. 18TYRCh. 16 - Olfactory neurons synapse with mitral cells and...Ch. 16 - In the phenomenon of ______, pain from the viscera...Ch. 16 - bin-Ch. 16 - decuss-Ch. 16 - hemi-Ch. 16 - lacrimo-Ch. 16 - litho-Ch. 16 - maculo-Ch. 16 - noci-Ch. 16 - scoto-Ch. 16 - -sepsisCh. 16 - Prob. 10BYMVCh. 16 - The sensory (afferent) nerve fibers for touch end...Ch. 16 - Prob. 2WWTSCh. 16 - Things we see with the left eye are perceived only...Ch. 16 - Prob. 4WWTSCh. 16 - The vitreous body occupies the posterior chamber...Ch. 16 - Prob. 6WWTSCh. 16 - Prob. 7WWTSCh. 16 - Prob. 8WWTSCh. 16 - Prob. 9WWTSCh. 16 - Prob. 10WWTSCh. 16 - The principle of neural convergence is explained...Ch. 16 - What type of cutaneous receptor enables you to...Ch. 16 - Prob. 3TYCCh. 16 - Prob. 4TYCCh. 16 - Prob. 5TYC
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- View History Bookmarks Window Help Quarter cements ents ons (17) YouTube Which amino acids would you expect to find marked on the alpha helix? canvas.ucsc.edu ucsc Complaint and Grievance Process - Academic Personnel pach orations | | | | | | | | | | | | | | | | 000000 000000000 | | | | | | | | | | | | | | | | | | | | | | 00000000 scope vious De 48 12.415 KATPM FEB 3 F1 F2 80 F3 a F4 F5 2 # 3 $ 85 % tv N A の Mon Feb 3 10:24 PM Lipid bilayer Submit Assignment Next > ZOOM < Å DII 8 བ བ F6 16 F7 F8 F9 F10 34 F11 F12 & * ( 6 7 8 9 0 + 11 WERTY U { 0 } P deletearrow_forwardDifferent species or organisms research for ecologyarrow_forwardWhat is the result of the following gram stain: positive ○ capsulated ○ acid-fast ○ negativearrow_forward
- What type of stain is the image below: capsule stain endospore stain gram stain negative stain ASM MicrobeLibrary.org Keplingerarrow_forwardWhat is the result of the acid-fast stain below: Stock Images by Getty Images by Getty Images by Getty Images by Getty Image Getty Images St Soy Getty Images by Getty Images by Getty Images Joy Getty encapsulated O endosporulating negative ○ positivearrow_forwardYou have a stock vial of diligence 75mg in 3ml and need to draw up a dose of 50mg for your patient.how many mls should you draw up to give this dosearrow_forward
- You are recquired to administer 150mg hydrocortisone intravenously,how many mls should you give?(stock =hydrocortisone 100mg in 2mls)arrow_forwardIf someone was working with a 50 MBq F-18 source, what would be the internal and external dose consequences?arrow_forwardWe will be starting a group project next week where you and your group will research and ultimately present on a current research article related to the biology of a pathogen that infects humans. The article could be about the pathogen itself, the disease process related to the pathogen, the immune response to the pathogen, vaccines or treatments that affect the pathogen, or other biology-related study about the pathogen. I recommend that you choose a pathogen that is currently interesting to researchers, so that you will be able to find plenty of articles about it. Avoid choosing a historical disease that no longer circulates. List 3 possible pathogens or diseases that you might want to do for your group project.arrow_forward
- not use ai pleasearrow_forwardDNK dagi nukleotidlar va undan sintezlangan oqsildagi peptid boglar farqi 901 taga teng bo'lib undagi A jami H boglardan 6,5 marta kam bo'lsa DNK dagi jami H bog‘lar sonini topingarrow_forwardOne of the ways for a cell to generate ATP is through the oxidative phosphorylation. In oxidative phosphorylation 3 ATP are produced from every one NADH molecule. In respiration, every glucose molecule produces 10 NADH molecules. If a cell is growing on 5 glucose molecules, how much ATP can be produced using oxidative phosphorylation/aerobic respiration?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Essentials of Pharmacology for Health ProfessionsNursingISBN:9781305441620Author:WOODROWPublisher:Cengage
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Essentials of Pharmacology for Health Professions
Nursing
ISBN:9781305441620
Author:WOODROW
Publisher:Cengage
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning