Microbiology with Diseases by Body System (5th Edition)
5th Edition
ISBN: 9780134477206
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Textbook Question
Chapter 16, Problem 3TMW
Why did scientists give the name perforin to a molecule secreted by Tc cells?
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Use the following choices for the next set of questions. A choice may be used zero or more times:
a)CD4
b) CD8
c) lg
d) TCR
e) More than one of these
26) Found on the cell surface
27) Expressed by T helper cells as a co-receptor
28) Expressed by B lymphocytes
29) Associated with cell that produces perforin
30) Composed of heavy and light chain
31) Capable of recognizing a carbohydrate antigen
32) Has effector functions
Which of the following is false when considering the CCR5Δ32 mutation?
a) The mutation prevents the entry of HIV-1 into a T cell.
b) The deletion that produced CCR5Δ32 caused a frameshift which extends the length of the protein product.
c) CCR5Δ32 prevents infection by HIV-1 in homozygotes but only delays the onset of HIV symptoms in heterozygotes.
d) The protein product produced by CCR5Δ32 is altered in such a manner that it cannot embed in the cell membrane.
Use the following choices for the next set of questions. A choice may be used zero or more times:
a)MHC class I
b) MHC class Il
C) both MHC class I and II
d) neither MHC class | or II
e) cannot be determined
21) expressed on T cells
22) captures antigens present in endosomes
23) strongly affected by proteasomal inhibition
24) downregulated by many viruses
25) the genes responsible for expression are monomorphic, meaning that identical alleles are shared throughout the population
Chapter 16 Solutions
Microbiology with Diseases by Body System (5th Edition)
Ch. 16 - Why are the activities of B and T cells called...Ch. 16 - Why are exogenous epitopes processed in vesicles...Ch. 16 - Why did scientists give the name perforin to a...Ch. 16 - Plasma cells are vital for protection against...Ch. 16 - Microsporidiosis Darius is sick, which is not...Ch. 16 - Why is passive immunity effective more quickly...Ch. 16 - Prob. 1MCCh. 16 - Prob. 2MCCh. 16 - Rejection of a foreign skin graft is an example of...Ch. 16 - An autoantigen is ________________. a. an antigen...
Ch. 16 - Among the key molecules that control cell-mediated...Ch. 16 - Which of the following lymphocytes predominates in...Ch. 16 - Prob. 7MCCh. 16 - Which cells express MHC class I molecules in a...Ch. 16 - In which of the following sites in the body can B...Ch. 16 - Tc cells recognize epitopes only when the latter...Ch. 16 - Prob. 1MTFCh. 16 - Prob. 2MTFCh. 16 - Prob. 3MTFCh. 16 - Prob. 4MTFCh. 16 - Prob. 5MTFCh. 16 - Match each cell in the left column with its...Ch. 16 - Match each type of immunity in the left column...Ch. 16 - Label the parts of the immunoglobulin below.Ch. 16 - The nearby image is a transmission electron...Ch. 16 - When is antigen processing an essential...Ch. 16 - Why does the body have both antibody and...Ch. 16 - Why is it advantageous for the lymphatic system to...Ch. 16 - Contrast innate defenses with adaptive immunity.Ch. 16 - How does requiring the immune system to process...Ch. 16 - Scientists can develop genetically deficient...Ch. 16 - Human immunodeficiency virus (HIV) preferentially...Ch. 16 - What would happen to a person who failed to make...Ch. 16 - Prob. 7CTCh. 16 - Some materials, such as metal bone pins and...Ch. 16 - Prob. 9CTCh. 16 - The cross-sectional area of the afferent lymphatic...Ch. 16 - Two students are studying for an exam on the bodys...Ch. 16 - In general, what sorts of pathogens might be able...Ch. 16 - What sorts of pathogens could successfully attack...Ch. 16 - As part of the treatment for some cancers,...Ch. 16 - Prob. 1CM
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- Why would attaching an enediyne- containing molecule to an antibody be an attractive way to treat cancer cells?arrow_forwardThe Fab regions of an antibody are made of which protein chain? A) a heavy chain containing only constant regions B) a light chain containing variable and constant regions C) a heavy chain containing variable and constant regions D) both a light chain and a heavy chain containing variable and constant regions E) both a light chain containing variable and constant regions and a heavy chain containing only constant regionsarrow_forwardCTLs use the following membrane-bound protein interactions to “kill” a target cell through apoptosis: Question 8 options: A) IL-2/IL-2 receptor B) CD4/MHC II C) TCR/MHC II D) Fas/FasLarrow_forward
- Which of the conformations illustrated above (a or b) is more likely PrPc (the normal cellular form of PrP) and which is more likely PrPSc (the pathogenic form of PrP)? Why?arrow_forwardWhich example would benefit most from the use of pluripotent stem cells made from the patient's own cells? A) An autoimmune disease, inappropriate targeting of the patient's immune system, destroyed a patient's thyroid gland B) A neurodegenerative disease, abnormal cell death of brain cells, destroyed a specific region of the patient's brain C) A patient suffered severe burns over much of their legs and feet D) A person with a congenital disease has been blind from birth.arrow_forwardExperiments are performed to analyze protein tyrosine phosphorylation in response to TCR stimulation. For these experiments, T cells are stimulated with anti-CD3 antibody, and then lysates are prepared and run on a protein (SDS-PAGE) gel to separate the proteins by molecular weight. The proteins are transferred from the gel to a membrane for immunoblotting using an antibody that binds to all phosphorylated tyrosine residues in any protein; this antibody is called ‘anti-phospho-tyrosine antibody,’ and is abbreviated as anti-P-Y. The results are shown in the figure below. You confirm that the mutant T cells express normal levels of all the proteins detected in the WT cells, including PLC-g, SLP-76, ITK, ZAP-70, LCK, LAT, and the CD3 and TCRz proteins. Based on these data, which of the following proteins (biotin, hygromycin, and streptavidin) can rule out its presence? Briefly explain your answer. What protein is most likely defective in the mutant cells and why? For the protein you…arrow_forward
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