The comparison of the effect of the drugs upon the single and combined use. The conclusions that can be drawn from the results regarding the combined effect of the DNA (deoxyribonucleic acid) methylation and histone acetylation on gene expression in these cells. Given: The table given below shows the individual as well as the combined effect of the drugs on the DNA methylation and histone acetylation. Treatment Untreated control of mRNA (messenger ribonucleic acid) transcript of: AZA TSA AZA+TSA Gene 1 7 23 25 Gene 2 <1 <1 11 Introduction: Two different compounds AZA and TSA are used to inhibit the enzymes DNA methyltransferase and histone deacetylase, respectively. The researchers studied the effects of the inhibitors both combinedly and separately.

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Chapter 16, Problem 2Q

Summary Introduction

To review:

The comparison of the effect of the drugs upon the single and combined use. The conclusions that can be drawn from the results regarding the combined effect of the DNA (deoxyribonucleic acid) methylation and histone acetylation on gene expression in these cells.

Given:

The table given below shows the individual as well as the combined effect of the drugs on the DNA methylation and histone acetylation.

Treatment

Untreated control of mRNA (messenger ribonucleic acid) transcript of: AZA TSA AZA+TSA

Gene 1 7 23 25

Gene 2 <1 <1 11

Introduction:

Two different compounds AZA and TSA are used to inhibit the enzymes DNA methyltransferase and histone deacetylase, respectively. The researchers studied the effects of the inhibitors both combinedly and separately.

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