LIFE:SCIENCE OF BIOL.(LL) >CUSTOM<
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ISBN: 9781319209957
Author: Sadava
Publisher: MAC HIGHER
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Chapter 16, Problem 2Q
Summary Introduction
To review:
The comparison of the effect of the drugs upon the single and combined use. The conclusions that can be drawn from the results regarding the combined effect of the DNA (deoxyribonucleic acid) methylation and histone acetylation on gene expression in these cells.
Given:
The table given below shows the individual as well as the combined effect of the drugs on the DNA methylation and histone acetylation.
| Treatment | |||
| Untreated control of mRNA (messenger ribonucleic acid) transcript of: | AZA | TSA | AZA+TSA |
| Gene 1 | 7 | 23 | 25 |
| Gene 2 | <1 | <1 | 11 |
Introduction:
Two different compounds AZA and TSA are used to inhibit the enzymes DNA methyltransferase and histone deacetylase, respectively. The researchers studied the effects of the inhibitors both combinedly and separately.
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Chapter 16 Solutions
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