MindTap for Des Jardins' Cardiopulmonary Anatomy & Physiology, 2 terms Printed Access Card
7th Edition
ISBN: 9781337794923
Author: Des Jardins, Terry
Publisher: Cengage Learning
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Chapter 16, Problem 2CAQ1
Summary Introduction
To review:
The reason for the development of prerenal abnormality in the given case.
Introduction:
An unconscious firefighter suffered from several second and third degree burns. The burns caused fluid sequestration. This resulted in hypovolemia, which decreases blood flow to the kidneys. A sharp reduction in the urine output and a low cardiac output have been observed.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
MindTap for Des Jardins' Cardiopulmonary Anatomy & Physiology, 2 terms Printed Access Card
Ch. 16 - 1. The outer one-third of the kidney is called...Ch. 16 - 2. Glomerular filtration is directly proportional...Ch. 16 - Prob. 3RQCh. 16 - Prob. 4RQCh. 16 - Prob. 5RQCh. 16 - 6. Which of the following can be classified as a...Ch. 16 - Prob. 7RQCh. 16 - Prob. 8RQCh. 16 - Prob. 9RQCh. 16 - Prob. 10RQ
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