CONNECT FOR ANATOMY AND PHYSIOLOGY >IC
11th Edition
ISBN: 9781260018462
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Question
Chapter 1.6, Problem 29AYP
Summary Introduction
To determine:
The serous membrane-lined cavities of the trunk.
Introduction:
The trunk is located in the central region of the body. It is further bifurcated into three parts: the thorax, the abdomen, and the pelvis. The serous membrane-lined cavities of the trunk wrap the organs inside the cavities.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 1 Solutions
CONNECT FOR ANATOMY AND PHYSIOLOGY >IC
Ch. 1.1 - How does the study of anatomy differ from the...Ch. 1.1 - What is studied in gross anatomy? In surface...Ch. 1.1 - Prob. 3AYPCh. 1.1 - Why are anatomy and physiology normally studied...Ch. 1.2 - From simplest to complex, list and define the...Ch. 1.2 - What are the four basic types of tissues?Ch. 1.2 - Referring to figure 1.3, which two organ systems...Ch. 1.3 - What are the six characteristics of living things?...Ch. 1.3 - How does differentiation differ from...Ch. 1.4 - Prob. 10AYP
Ch. 1.4 - How do variables, set points, and normal ranges...Ch. 1.4 - Prob. 12AYPCh. 1.4 - Prob. 13AYPCh. 1.4 - Give an example of how a negative-feedback...Ch. 1.4 - Prob. 15AYPCh. 1.6 - What is anatomical position in humans? Why is it...Ch. 1.6 - What two directional terms indicate “toward the...Ch. 1.6 - What two directional terms indicate “the bock” in...Ch. 1.6 - Define the following directional terms and give...Ch. 1.6 - What makes up the central region of the body?Ch. 1.6 - What is the difference between the arm and the...Ch. 1.6 - What are the anatomical terms for the following...Ch. 1.6 - In what quadrant would the majority of the stomach...Ch. 1.6 - List and describe the three planes of the body.Ch. 1.6 - In what three ways can you cut an organ?Ch. 1.6 - What structure separates the thoracic cavity from...Ch. 1.6 - What structure divides the thoracic cavity into...Ch. 1.6 - What is a serous membrane and its function?...Ch. 1.6 - Prob. 29AYPCh. 1.6 - What are mesenteries? Explain their function.Ch. 1.6 - What are retroperitoneal organs? List five...Ch. 1 - Physiology a. deals with the processes or...Ch. 1 - The following are organizational levels for...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - For questions 3-7, match each organ system with...Ch. 1 - The characteristic of life that is defined as “all...Ch. 1 - The following events are part of a...Ch. 1 - Which of these statements concerning positive...Ch. 1 - A term that means nearer the attached end of a...Ch. 1 - Which of these directional terms are paired most...Ch. 1 - The part of the upper limb between the elbow and...Ch. 1 - A patient with appendicitis usually has pain in...Ch. 1 - A plane that divides the body into anterior and...Ch. 1 - The lungs are Part of the mediastinum. Surrounded...Ch. 1 - Given the following organ and cavity combinations:...Ch. 1 - Which if the following membrane combination are...Ch. 1 - Which of the following organs are not...Ch. 1 - Prob. 1CTCh. 1 - A male has lost blood as a result of a gunshot...Ch. 1 - Provide the correct directional term for the...Ch. 1 - During pregnancy, which of the mother’s body...Ch. 1 - A woman falls while skiing and is accidentally...
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