HUMAN ANATOMY + PHYSIOLOGY + MAST AP
HUMAN ANATOMY + PHYSIOLOGY + MAST AP
11th Edition
ISBN: 9780136782056
Author: Marieb
Publisher: INTER PEAR
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Chapter 16, Problem 26RQ
Summary Introduction

To review:

The following statements regarding the given case study:

(a) Reason for low plasma sodium ion concentration and high plasma potassium.

(b) Reason for doing the Adrenocorticotropic hormone (ACTH) stimulation test

(c)The gland that mainly affects in case ACTH does not lead to a normal increase of the cortisol secretion and the name of this abnormality.

(d)The gland that mainly affects in case ACTH causes an increase in the secretion of cortisol.

Introduction:

A 42-year-old single father named Aaron meets his physician with a complaint of nausea and chronic fatigue. Then he reported of having felt listless and fatigued for about half a year. However, he had attributed this toward the stress. The father lost his weight considerably and strangely his skin seems to be tanned and he spends long hours at work and it is rare ventures outside.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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