Essentials of Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780321919007
Author: Elaine N. Marieb
Publisher: PEARSON
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Chapter 16, Problem 17SAE
Summary Introduction
To review:
The definition of the biological terminology “ejaculation.”
Introduction:
The cup-shaped organ known as epididymis is known to be a highly convoluted tube 6 meters in length that covers the posterior area of the testis. It is known to be the first part of the duct system in men. It serves as a short-term storage area for the immature sperms.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 16 Solutions
Essentials of Human Anatomy & Physiology (11th Edition)
Ch. 16 - More than one choice may apply.
1. Which of the...Ch. 16 - 2. In terms of development, which of these pairs...Ch. 16 - Prob. 3MCCh. 16 - Prob. 4MCCh. 16 - The approximate area between the anus and clitoris...Ch. 16 - 6. Which of the following attach to the...Ch. 16 - Prob. 7MCCh. 16 - Prob. 8MCCh. 16 - More than one choice may apply. Which of the...Ch. 16 - After ovulation, the ruptured follicle a....
Ch. 16 - The outer layer of the blastocyst, which attaches...Ch. 16 - Prob. 12MCCh. 16 - During human embryonic development, organogenesis...Ch. 16 - What are the endocrine and exocrine functions of...Ch. 16 - Prob. 15SAECh. 16 - How does semen provide an ideal environment for...Ch. 16 - Prob. 17SAECh. 16 - Prob. 18SAECh. 16 - 19. How does enlargement of the prostate interfere...Ch. 16 - What is the function of the acrosome?Ch. 16 - Prob. 21SAECh. 16 - 22. Explain why a man’s sexual responsiveness and...Ch. 16 - Prob. 23SAECh. 16 - Prob. 24SAECh. 16 - 25. Name the structures of the female duct system,...Ch. 16 - Prob. 26SAECh. 16 - Prob. 27SAECh. 16 - Prob. 28SAECh. 16 - Prob. 29SAECh. 16 - List and describe the events of the menstrual...Ch. 16 - Prob. 31SAECh. 16 - Prob. 32SAECh. 16 - Prob. 33SAECh. 16 - Prob. 34SAECh. 16 - Prob. 35SAECh. 16 - What is the indifferent stage of embryonic...Ch. 16 - Prob. 37SAECh. 16 - 38. Compare the effects of aging on the male and...Ch. 16 - Prob. 39CAQCh. 16 - Prob. 40CAQCh. 16 - James has been home from university over the...
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