Seeley's Anatomy & Physiology
11th Edition
ISBN: 9780077736224
Author: Cinnamon VanPutte, Jennifer Regan, Andrew F. Russo Dr., Rod R. Seeley Dr.
Publisher: McGraw-Hill Education
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Chapter 15.4, Problem 41AYP
What is the importance of the sound attenuation reflex?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 15 Solutions
Seeley's Anatomy & Physiology
Ch. 15.1 - Where are olfactory neurons located? Explain their...Ch. 15.1 - Describe the initiation of an action potential in...Ch. 15.1 - What is unique about olfactory neurons with...Ch. 15.1 - Where are the central olfactory cortex areas...Ch. 15.2 - Name and describe the four kinds of papillae on...Ch. 15.2 - Describe the structure of a taste bud.Ch. 15.2 - What are the five primary tastes? Describe how...Ch. 15.2 - Prob. 8AYPCh. 15.2 - How is the sense of taste related to the sense of...Ch. 15.3 - Prob. 10AYP
Ch. 15.3 - How do the conjunctiva,lacrimal apparatus, and...Ch. 15.3 - Prob. 12AYPCh. 15.3 - How does the pupil constrict? How does it dilate?Ch. 15.3 - Prob. 14AYPCh. 15.3 - Name the three chambers of the eye and the...Ch. 15.3 - Prob. 16AYPCh. 15.3 - Prob. 17AYPCh. 15.3 - Prob. 18AYPCh. 15.3 - Prob. 19AYPCh. 15.3 - Prob. 20AYPCh. 15.3 - Prob. 21AYPCh. 15.3 - Prob. 22AYPCh. 15.3 - Describe the changes that occur in a rod cell...Ch. 15.3 - Prob. 24AYPCh. 15.3 - Prob. 25AYPCh. 15.3 - Prob. 26AYPCh. 15.3 - Prob. 27AYPCh. 15.3 - Prob. 28AYPCh. 15.3 - Starting with the optic nerve, trace the action...Ch. 15.3 - Prob. 30AYPCh. 15.4 - Name the three regions of the ear, and list each...Ch. 15.4 - Describe the relationship among the tympanic...Ch. 15.4 - What are the functions of the external auditory...Ch. 15.4 - Explain how the membranous labyrinth of the...Ch. 15.4 - Describe the structure of the spiral organ.Ch. 15.4 - Explain the differences between inner and outer...Ch. 15.4 - Relate how tip links function.Ch. 15.4 - Prob. 38AYPCh. 15.4 - Contrast volume, pitch, and timbre.Ch. 15.4 - Starting with the auricle, trace a sound wave into...Ch. 15.4 - What is the importance of the sound attenuation...Ch. 15.4 - Prob. 42AYPCh. 15.4 - Describe the neuronal pathways for hearing, from...Ch. 15.4 - Prob. 44AYPCh. 15.4 - Prob. 45AYPCh. 15.4 - What is dynamic equilibrium? Whatstructures are...Ch. 15.4 - Prob. 47AYPCh. 15.4 - Prob. 48AYPCh. 15.5 - Prob. 49AYPCh. 15 - Which of these statements is not true with respect...Ch. 15 - Prob. 2RACCh. 15 - Which of these is not one of the basic tastes? a....Ch. 15 - Which of these types of papillae have no taste...Ch. 15 - Prob. 5RACCh. 15 - The ciliary body a. contains smooth muscles that...Ch. 15 - Prob. 7RACCh. 15 - Prob. 8RACCh. 15 - Prob. 9RACCh. 15 - Prob. 10RACCh. 15 - Prob. 11RACCh. 15 - Prob. 12RACCh. 15 - Prob. 13RACCh. 15 - In the retina cones that are most sensitive to a...Ch. 15 - Given these areas of the retina: (1) macula (2)...Ch. 15 - Prob. 16RACCh. 15 - Prob. 17RACCh. 15 - Which of these structures is found within or is...Ch. 15 - Prob. 19RACCh. 15 - Prob. 20RACCh. 15 - Prob. 21RACCh. 15 - Prob. 22RACCh. 15 - Prob. 23RACCh. 15 - Prob. 24RACCh. 15 - Damage to the semicircular canals affects the...Ch. 15 - Prob. 1CTCh. 15 - Perhaps you have heard that eating carrots is good...Ch. 15 - A man stares at a black clock on a white wall for...Ch. 15 - Prob. 4CTCh. 15 - Prob. 5CTCh. 15 - Prob. 6CTCh. 15 - Professional divers are subject to increased...Ch. 15 - If a vibrating tuning fork is placed against the...
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