Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
10th Edition
ISBN: 9780133922851
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Videos
Question
Chapter 15.4, Problem 3CC
Summary Introduction
To determine: The activation of the gene on Philadelphia chromosome that codes for intracellular tyrosine kinase, contributing to the development of cancer.
Concept introduction:
Tyrosine kinase belongs to the group of protein kinases. It catalyzes the addition of a phosphate group from the ATP molecule generated, to a protein molecule. This addition aids in transferring a signal that induces the cell to divide.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
List and describe 4 of the main regulators of the cell cycle. Then describe the involvement of a CDK substrate at each stage of the cell cycle: G1, S, G2, M.
2. DESCRIBE (do not just list) three mechanisms that keep the cell cycle moving in only one direction. Then describe how these mechanisms play a role at one specific stage of the cell cycle.
3. What are the three main classes of genes implicated in cancer? Describe each one and give an example of each one.
4. DESCRIBE (do not just list) 4 developmental strategies that cause different cells and tissues to acquire different identities during embryogenesis. Then explain how iPS cells are an exception to the overall trend of cells decreasing in pluripotency as they develop.
5. Describe three unique cell biological features of sperm cells and three unique cell biological features of egg cells. By "unique", I mean a feature that is not common in most cells.
6. You have just identified a mouse gene that is homologous to other vertebrate…
Modify the diagram above to illustrate specific protein(s) that would participate in regulating this pathway if DNA damage was detected in these cells. What effect would this have on the progression of the cell cycle? If there is more than one possible outcome be sure to outline each one.
Describe what happens to the G1 cell cycle check point of a skin cell that is stimulated to divide by neighboring cells following an injury. Describe the pathway from the growth factor signal to the cell cycle checkpoint regulation of gene expression resulting in cell duplication. Briefly explaining the mechanism
Chapter 15 Solutions
Campbell Biology, Books a la Carte Plus Mastering Biology with eText -- Access Card Package (10th Edition)
Ch. 15.1 - Which one of Mendel's laws describes the...Ch. 15.1 - MAKE CONNECTIONS Review the description of...Ch. 15.1 - WHAT IF? Propose a possible reason that the first...Ch. 15.2 - A white-eyed female Drosophila is mated with a...Ch. 15.2 - Neither Tim nor Rhoda has Duchenne muscular...Ch. 15.2 - MAKE CONNECTIONS Consider what you learned about...Ch. 15.3 - When two genes are located on the same chromosome,...Ch. 15.3 - VISUAL SKILLS For each type of offspring of the...Ch. 15.3 - Prob. 3CCCh. 15.4 - Prob. 1CC
Ch. 15.4 - Prob. 2CCCh. 15.4 - Prob. 3CCCh. 15.5 - Gene dosagethe number of copies of a gene that are...Ch. 15.5 - Reciprocal crosses between two primrose varieties,...Ch. 15.5 - WHAT IF? Mitochondrial genes are critical to the...Ch. 15 - What characteristic of the sex chromosomes allowed...Ch. 15 - Why are males affected by X-Iinked disorders much...Ch. 15 - Why are specific alleles of two distant genes more...Ch. 15 - Prob. 15.4CRCh. 15 - Explain how genomic imprinting and inheritance of...Ch. 15 - A man with hemophilia (a recessive, sex-linked...Ch. 15 - Pseudohypertrophic muscular dystrophy is an...Ch. 15 - A wild-type fruit fly (heterozygous for gray body...Ch. 15 - A planet is inhabited by creatures that reproduce...Ch. 15 - Using the information from problem 4, scientists...Ch. 15 - A wild-type fruit fly (heterozygous for gray body...Ch. 15 - Assume that genes, A and B are on the same...Ch. 15 - Two genes of a flower, one Controlling blue (B)...Ch. 15 - You design Drosophila crosses to provide...Ch. 15 - Banana plants, which are triploid, are seedless...Ch. 15 - EVOLUTION CONNECTION Crossing over is thought to...Ch. 15 - SCIENTIFIC INQUIRY DRAW IT Assume you are mapping...Ch. 15 - WRITE ABOUT A THEME: INFORMATION The continuity of...Ch. 15 - SYNTHESIZE YOUR KNOWLEDGE Butter flies have an X-Y...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- . MAKE CONNECTIONS The p53 protein can activategenes involved in apoptosis. Review Concept 11.5, anddiscuss how mutations in genes coding for proteins thatfunction in apoptosis could contribute to cancer.arrow_forwardExplain the concept of loss of heterozygosity (LOH). Why do most cancer cells exhibit LOH of one or more genes? How does failure of the spindle assembly checkpoint lead to loss of heterozygosity?arrow_forwardDescribe the effects of the over-expression of mdm2 on cell proliferation and apoptosis on cell signaling pathways and metabolism or cell cycle control. Briefly explain the normal role of each component in the context of the pathway and why its loss or modification would have the expected effect.arrow_forward
- Describe how Ras and p53 can alter the simplified genetic pathway controlling cell division shown below. For each of the two genes, would uncontrolled cell division result from a loss-of-function or a gain-of-function mutation? growth factors - receptors - cyclins - cyclin-dependent kinases - cell divisionarrow_forwardDiscuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.arrow_forwardPart A and B A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle checkpoint inhibitor B) Loss of expression of a growth factor that promotes cell cycle entry C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry D) Overexpression of a DNA damage repair enzyme E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle? A) They promote the G1 to S checkpoint B) They normally inhibit M phase from being completed C) They form the mitotic spindle E) They mediate DNA replication F) They form the cleavage furrow during cytokinesisarrow_forward
- Describe the effects of the mutation causing the p21 promoter to no longer bind p53 on cell signaling pathways and metabolism or cell cycle control.arrow_forwardQ. Cyclins and CDK(inase) complexes regulate the cell cycle. Which of the following statements is true? A. Cyclins activate CDKs which remove phosphates from other proteins. B. Cyclins activate CDKs which add phosphates to other proteins. C. CDKs activate cyclins which remove phosphates from other proteins. D. CDKs activate cyclins which add phosphates to other proteins.arrow_forwardWhich of the following statements is a lie? Select one: a. The p21 is a multi-functional protein that regulates cell growth and monitors DNA damage on the cells undergoing the preparatory processes during G1. b. Cyclins and Cyclin-dependent kinases (Cdk) need to be tightly bound with each other to regulate the cell cycle by phosphorylating and activating other proteins to advance the cell to the next phase. c. The negative regulators halt the cell cycle and these include Retinoblastoma protein (Rb), p53, and p21.arrow_forward
- When regulating the cell cycle of eukaryotic cells, a critical protein we discussed was cyclin. Cyclin is Select one: a. Always present in all stages of the cell cycle, but only active during the G1 - R transition b. Produced in response to signals for the cell to divide c. Produced only when retinoblastoma protein is inactivated d. Produced in response to the presence of cyclin-dependent kinasearrow_forwardPredict the effects of the following mutations on the ability of a cell to undergo apoptosis:a. Mutation in Bad such that it cannot be phosphorylated by protein kinase B (PKB)b. Overexpression of Bcl-2c. Mutation in Bax such that it cannot form homodimersOne common characteristic of cancer cells is a loss of function in the apoptotic pathway. Which of the mutations listed above might you expect to find in some cancer cells?arrow_forwardDiscuss about Surveillance Mechanisms in Cell Cycle Regulationarrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax College
Biology 2eBiologyISBN:9781947172517Author:Matthew Douglas, Jung Choi, Mary Ann ClarkPublisher:OpenStax
Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)BiologyISBN:9781305389892Author:Peter J. Russell, Paul E. Hertz, Beverly McMillanPublisher:Cengage Learning
Concepts of Biology
Biology
ISBN:9781938168116
Author:Samantha Fowler, Rebecca Roush, James Wise
Publisher:OpenStax College
Biology 2e
Biology
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:OpenStax
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Biology: The Dynamic Science (MindTap Course List)
Biology
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Cengage Learning
What are Mutations and what are the different types of Mutations?; Author: Science ABC;https://www.youtube.com/watch?v=I16YlE8qTBU;License: Standard youtube license