Concept explainers
To review:
The similarities and differences between endotoxins and exotoxins on the following aspects: bacterial source, chemistry, toxicity, and pharmacology.
Introduction:
Microorganisms that have the ability to cause infectious diseases are called as pathogens. Such microorganisms include bacteria,
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Microbiology: An Introduction (13th Edition)
- Here are four toxins: diphtheria toxin, cholera toxin, tetanus toxin, and exfoliative toxin. Choose two of them and answer the following questions: 1. Is it an exotoxin or an endotoxin? 2. Which bacterial species produces it? 3. Briefly describe its mode of action and how it causes damage to the host cells. Include specific signs and symptoms.arrow_forwardEndotoxin is associated witha) Gram-positive bacteria.b) Gram-negative bacteria.c) the cytoplasmic membrane.d) endospores.arrow_forwardChoose one infectious disease from the list below and use the chain of infection to analyze how it is spread. A. Please provide a comprehensive description of cholera. B. Describe the chain of infection cholera. The chain of infection for the chosen infectious disease must clearly include the following: 1. Identification of a) the pathogen, b) the reservoir c) means of transmission d) the susceptible host 2. Describe how one could break the chain of cholera, such as breaking the pathogen link, by providing a specific intervention. 3. Include references and relevant data.arrow_forward
- Selective toxicity of a drug refers to a) damage to pathogenic organisms only b) damage to prokaryotic cell membranes c) damage to the target organisms but not the host cell d) easily broken down by the host and pathogen.arrow_forwardDefine 43-kDa connexinarrow_forwardWhich of the following types of antimicrobial drugs make microbes more susceptible to osmotic pressure? 1) drugs that inhibit nucleic acid synthesis O 2) drugs that inhibit metabolic pathways 3) drugs that inhibit cell wall synthesis 4) drugs that block a pathogen's recognition of its host 5) drugs that inhibit protein synthesisarrow_forward
- Which one of the following categories for antibacterial agents is most likely to have toxic side effects for humans? a) disruptors of cell membrane structure b) inhibitors of cell wall synthesis Oc) inhibitors of protein synthesis d) antimetabolites RESET e) inhibitors of DNA synthesis Cancel Donearrow_forwardGive detailed Solution. Don't give Ai generated solutionarrow_forwardCompare exotoxin from endotoxin based on the following features FEATURE EXOTOXIN ENDOTOXIN Relation to cell Toxicity Stability Antigenicity Conversion to toxoidarrow_forward
- Foodborne pathogens often require the presence of a large number of microbes before an active infection results. These microbes would have a high A.) median infectious dose (ID50). B.) incubation period. C.) virulence. D.) median lethal dose (LD50). E.) mortality.arrow_forwardBelow are listed the LD-50 values for toxins from specific isolates of a bacterial species. Which toxin would be considered the "most lethal"?Diptheria toxin . .1 mg/kgClostridium difficile enterotoxin A .5 mg/kgV. cholerae toxin 250 mg/kgB. pertussis toxin 15 mg/kg a)diptheria toxin b)enterotoxin A c)V. cholerae toxin d)B. pertussis toxinarrow_forwardBelow are a list of virulence factors/ strategies paired with an example of an organism that utilizes them. How do each of the following strategies contribute to the virulence of the pathogen? Strategy - Causes the host to produce more receptors (Organism - Rhinovirus) Strategy - Produces gas as a product of fermentation (Organism - Clostridium perfringens) Strategy - Produces a capsule (organism - Klebsiella pneumonia) Strategy - Ability to move between adjacent cells (organism - Cytomegalovirus) Strategy - Ability to use pilus as a motility structure (organism - Pseudomonas aerogenosa)arrow_forward
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