Biology: Life on Earth
Biology: Life on Earth
10th Edition
ISBN: 9780321729712
Author: Gerald Audesirk, Teresa Audesirk, Bruce E. Byers
Publisher: Benjamin Cummings
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Chapter 15, Problem 2AC

Malaria is rare in North America. In populations of African Americans, what would you predict is happening to the frequency of the hemoglobin allele that leads to sickling in red blood cells? How would you go about determining whether your prediction is true?

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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