Essentials of Human Anatomy & Physiology
Essentials of Human Anatomy & Physiology
11th Edition
ISBN: 9780133481662
Author: Elaine N. Marieb
Publisher: PEARSON
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Chapter 15, Problem 21SAE
Summary Introduction

To review:

The role of the respiratory system in regulating acid–base balance.

Introduction:

Maintenance of the acid–base balance in the blood is important for the proper functioning of the cells. The optimum blood pH range is 7.3 to 7.45. The rise in blood pH above the normal range causes alkalosis, whereas the fall of blood pH is known as acidosis.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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