If a point mutation occurs within a human egg cell genome that changes an A to a T, what is the most likely effect of this mutation on the phenotype of an offspring that develops from this mutated egg?

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Answer 1

Textbook Question

Chapter 15, Problem 1NST

If a point mutation occurs within a human egg cell genome that changes an A to a T, what is the most likely effect of this mutation on the phenotype of an offspring that develops from this mutated egg?

Expert Solution & Answer

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.

Conclusion

Thus, the phenotypic effect of point mutation depends on the location of the base pair, interaction with base pair, and potential of base pair.

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Students have asked these similar questions

Imagine that you are a clinical geneticist. Your colleague is an oncologist who wants your help explaining the basics of genetics to their patient, who will be undergoing genetic testing in the coming weeks for possible acute myeloid leukemia (AML) induced by the radiation she had several years ago for breast cancer. Write a 1,050- to 1,225-word memo to your colleague. Include the following in your memo: An explanation of the molecular structure of DNA and RNA, highlighting both similarities and differences A description of the processes of transcription and translation An explanation of the differences between leading and lagging strands and how the DNA is replicated in each strand Reponses to the following common questions patients might ask about this type of genetic testing and genetic disorder: Does AML run in families? What genes are tested for?

Respond to the following in a minimum of 175 words: What are some potential consequences that could result if the processes of replication, transcription, and translation don’t function correctly? Provide an example of how you might explain these consequences in terms that patients might understand.

answer questions 1-10

Answer 2

Textbook Question

Chapter 15, Problem 1NST

If a point mutation occurs within a human egg cell genome that changes an A to a T, what is the most likely effect of this mutation on the phenotype of an offspring that develops from this mutated egg?

Expert Solution & Answer

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.

Conclusion

Thus, the phenotypic effect of point mutation depends on the location of the base pair, interaction with base pair, and potential of base pair.

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Answer 3

Textbook Question

Chapter 15, Problem 1NST

If a point mutation occurs within a human egg cell genome that changes an A to a T, what is the most likely effect of this mutation on the phenotype of an offspring that develops from this mutated egg?

Expert Solution & Answer

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.

Conclusion

Thus, the phenotypic effect of point mutation depends on the location of the base pair, interaction with base pair, and potential of base pair.

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Answer 4

Textbook Question

Chapter 15, Problem 1NST

If a point mutation occurs within a human egg cell genome that changes an A to a T, what is the most likely effect of this mutation on the phenotype of an offspring that develops from this mutated egg?

Expert Solution & Answer

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.

Conclusion

Thus, the phenotypic effect of point mutation depends on the location of the base pair, interaction with base pair, and potential of base pair.

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Answer 5

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Answer 6

Textbook Question

Answer 7

Expert Solution & Answer

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.

Conclusion

Thus, the phenotypic effect of point mutation depends on the location of the base pair, interaction with base pair, and potential of base pair.

Answer 8

Expert Solution & Answer

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.

Conclusion

Thus, the phenotypic effect of point mutation depends on the location of the base pair, interaction with base pair, and potential of base pair.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Summary Introduction

To determine: The phenotypic effect of a point mutation in an offspring.

Introduction: A change of one base pair to another in a DNA molecule is called point mutation. A change of one nucleotide of a triplet within a protein-coding portion of a gene results in a new triplet that codes for a different amino acid in the protein product.

Answer 12

Explanation of Solution

The phenotypic effect of any base change is dependent on a number of factors. These factors are as follows:

Location of the base pair in coding or noncoding region.
Interaction with other base sequences in the genome.
Base pair potential in dominance or recessiveness.

If a base change is located in a noncoding region, there may be no influence on the phenotype. Some noncoding region serves regulatory functions. The mutations that influence transcription levels, polyA addition, splicing, and translation can affect phenotype.

If a mutation occurs in a coding region that acts as a full recessive, there should be no influence on the phenotype. If a mutant gene acts as a dominant, then there would be an influence on the phenotype.