Essential Cell Biology (Fourth Edition)
Essential Cell Biology (Fourth Edition)
4th Edition
ISBN: 9780815345251
Author: Bruce Alberts, Dennis Bray, Karen Hopkin, Alexander D. Johnson, Julian Lewis, Martin Raff, Keith Roberts, Peter Walter
Publisher: W. W. Norton & Company
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Chapter 15, Problem 16Q
Summary Introduction

To compare: The protein import into the ER and into the nucleus.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

Summary Introduction

To explain: The reason that the ER mechanism might not work for nuclear import and vice versa.

Concept introduction: For the proteins to import into the nucleus, the nuclear localization signal or sequence must tag the protein to be imported. Importin proteins will be present to bind the cargo protein so that they can interact with the nuclear pore complex and can pass through the channel. The protein import into the ER occurs co-translationally by the ribosomes on the ER with the translated protein going through a protein pore called translocator.

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