CAMPBELL BIOLOGY (18W)
CAMPBELL BIOLOGY (18W)
12th Edition
ISBN: 9780136858256
Author: Urry
Publisher: PEARSON
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Chapter 14.4, Problem 1CC
Summary Introduction

To know: The probability for two genetic crosses in the given case.

Introduction: Cystic fibrosis is a disease that is caused due to defective genes. It is a recessive disorder that is passed on to children by their parents. It can affect the lungs, pancreas, and digestive system. It is caused when both parents are carrying one recessive gene and children must inherit both genes in order to get affected.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.

Chapter 14 Solutions

CAMPBELL BIOLOGY (18W)

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