CONNECT WITH LEARNSMART FOR COWAN: MICR
CONNECT WITH LEARNSMART FOR COWAN: MICR
3rd Edition
ISBN: 2818440123740
Author: Cowan
Publisher: MCG
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Chapter 14.2, Problem 2NP
Summary Introduction

Introduction:

Anaphylaxis is an acute allergic reaction. Its symptoms include shortness of breath, itchy rash, tongue swelling, vomiting, low blood pressure, and light-headedness. Anaphylaxis is rapid in onset and may also be lethal. In an anaphylactic shock, the heart is unable to pump enough

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.

Chapter 14 Solutions

CONNECT WITH LEARNSMART FOR COWAN: MICR

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