SEELEY'S ANATOMY CUSTOM LL
11th Edition
ISBN: 9781260533699
Author: VanPutte
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 14.2, Problem 21AYP
What are the three functional parts of the cerebellum, and what are the functions of each?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 14 Solutions
SEELEY'S ANATOMY CUSTOM LL
Ch. 14.1 - In general, into what three groups con sensory...Ch. 14.1 - List the eight major types of sensory receptors,...Ch. 14.1 - Prob. 3AYPCh. 14.1 - Prob. 4AYPCh. 14.1 - Prob. 5AYPCh. 14.1 - Prob. 6AYPCh. 14.1 - Prob. 7AYPCh. 14.1 - How do descending pathways modulate sensation?Ch. 14.1 - Prob. 9AYPCh. 14.1 - Describe the spatial organization of the general...
Ch. 14.1 - Prob. 11AYPCh. 14.2 - Prob. 12AYPCh. 14.2 - Prob. 13AYPCh. 14.2 - Prob. 14AYPCh. 14.2 - Prob. 15AYPCh. 14.2 - What two tracts form the direct pathways? What...Ch. 14.2 - Describe the location of the neurons in each...Ch. 14.2 - Name the structures and tracts that form the...Ch. 14.2 - Prob. 19AYPCh. 14.2 - Prob. 20AYPCh. 14.2 - What are the three functional parts of the...Ch. 14.2 - Explain the comparator activities of the...Ch. 14.2 - What are the general symptoms of cerebellar...Ch. 14.3 - Prob. 24AYPCh. 14.3 - Prob. 25AYPCh. 14.3 - Discuss the somatic motor output and reflexes from...Ch. 14.3 - Prob. 27AYPCh. 14.3 - Prob. 28AYPCh. 14.4 - Prob. 29AYPCh. 14.4 - Prob. 30AYPCh. 14.4 - Prob. 31AYPCh. 14.4 - Prob. 32AYPCh. 14.4 - What conditions produce alpha, beta, theta. and...Ch. 14.4 - Prob. 34AYPCh. 14.4 - Prob. 35AYPCh. 14.4 - Prob. 36AYPCh. 14.4 - Distinguish between declarative and procedural...Ch. 14.4 - Prob. 38AYPCh. 14.4 - Prob. 39AYPCh. 14.5 - Prob. 40AYPCh. 14.5 - Prob. 41AYPCh. 14.5 - Does aging always produce memory loss?Ch. 14 - Prob. 1RACCh. 14 - Prob. 2RACCh. 14 - Prob. 3RACCh. 14 - Prob. 4RACCh. 14 - Prob. 5RACCh. 14 - Prob. 6RACCh. 14 - Prob. 7RACCh. 14 - Prob. 8RACCh. 14 - Tertiary neurons in both the spinothalamic tract...Ch. 14 - Prob. 10RACCh. 14 - Prob. 11RACCh. 14 - Prob. 12RACCh. 14 - Prob. 13RACCh. 14 - Prob. 14RACCh. 14 - Prob. 15RACCh. 14 - Prob. 16RACCh. 14 - Prob. 17RACCh. 14 - Prob. 18RACCh. 14 - Which of these pathways is not an indirect...Ch. 14 - Prob. 20RACCh. 14 - The major effect of the basal nuclei is a. to act...Ch. 14 - Which part of the cerebellum is correctly matched...Ch. 14 - Prob. 23RACCh. 14 - Prob. 24RACCh. 14 - Prob. 25RACCh. 14 - The main connection between the right and left...Ch. 14 - Prob. 27RACCh. 14 - Prob. 28RACCh. 14 - Prob. 29RACCh. 14 - Prob. 30RACCh. 14 - Describe all the sensations and perceptions...Ch. 14 - Prob. 2CTCh. 14 - Prob. 3CTCh. 14 - Prob. 4CTCh. 14 - Prob. 5CTCh. 14 - Prob. 6CTCh. 14 - Prob. 7CTCh. 14 - Prob. 8CTCh. 14 - Prob. 9CT
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