Chapter 14.12, Problem 29ATS

Interpretation Introduction

Interpretation: The synthesis for the given transformation has to be done.

Concept Introduction:

Epoxides are taken as the starting material and Grignard reagent are used to modify the structure of the starting material.

In this reaction, the Epoxide is opened and the alkyl group is made to come in contact with the structure.

Williamson ether synthesis is one of the methods to synthesize Ethers. It involves in two steps.

The first step involves the deprotonation of Alcohol to Alkoxide ion

The second step involves in the nucleophilic attack of Alkoxide ion by a ${\text{S}}_{\text{N}}\text{2}$ mechanism.

Mechanism:

A hydride ion acts as a base and deprotonation of Alcohol takes places.

The Alkoxide ion acts as nucleophile and attacks the alkyl halide by ${\text{S}}_{\text{N}}\text{2}$ process.