HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
19th Edition
ISBN: 9780135672990
Author: AMERMAN
Publisher: Pearson Custom Publishing
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Textbook Question
Chapter 14.1, Problem 5QC
What are the two divisions of the ANS?
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 14 Solutions
HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
Ch. 14.1 - What are the basic functions of the ANS?Ch. 14.1 - 2. What are autonomic ganglia?
Ch. 14.1 - How do somatic motor neurons and autonomic neurons...Ch. 14.1 - 4. What are preganglionic and postganglionic...Ch. 14.1 - What are the two divisions of the ANS?Ch. 14.1 - How are the two divisions of the ANS alike, and...Ch. 14.2 - 1. Where are the cell bodies of sympathetic...Ch. 14.2 - Where are the cell bodies of sympathetic...Ch. 14.2 - Which neurotransmitter(s) is (are) released by...Ch. 14.2 - Prob. 4QC
Ch. 14.2 - Describe the effects of the sympathetic nervous...Ch. 14.2 - Prob. 6QCCh. 14.3 - What is the basic function of the parasympathetic...Ch. 14.3 - Where are the preganglionic parasympathetic cell...Ch. 14.3 - How does the arrangement of neurons in the...Ch. 14.3 - 4. Which neurotransmitter is released by all...Ch. 14.3 - Prob. 5QCCh. 14.3 - Prob. 6QCCh. 14.3 - Summarize the effects of the parasympathetic...Ch. 14.4 - Prob. 1QCCh. 14.4 - Prob. 2QCCh. 14.4 - 3. What is autonomic tone?
Ch. 14.4 - How does the CNS mediate control over the ANS?Ch. 14 - Which of the following best describes the basic...Ch. 14 - 2. Fill in the blanks: The sympathetic nervous...Ch. 14 - 3. Sympathetic preganglionic neurons synapse:
a....Ch. 14 - Differentiate between adrenergic and cholinergic...Ch. 14 - Prob. 5CYRCh. 14 - Explain what happens when sympathetic neurons...Ch. 14 - Prob. 7CYRCh. 14 - Mark each of the following as an effect of the...Ch. 14 - Mark the following statements as true or false. If...Ch. 14 - 10. Fill in the blanks: _______receptors are...Ch. 14 - Parasympathetic ganglia are typically: a. located...Ch. 14 - Central nervous system control over the ANS is...Ch. 14 - 1. Using 20 or fewer words, define each of the...Ch. 14 - You are running a race to the top of a mountain....Ch. 14 - 3. Describe all the changes initiated by the...Ch. 14 - 1. Which cranial nerves would be affected by a...Ch. 14 - 2. A patient, Dr. Young, has both asthma and high...Ch. 14 - Mr. Chevalier has been diagnosed with Horner...Ch. 14 - Many chemical warfare agents, such as the...
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