The probability of birth of a child with sickle-cell disease, if both spouses are predicted to be carriers of recessive allele causing sickle-cell disease. Concept introduction: During gamete formation, two alleles of a gene segregate into different gametes. This is based on Mendel’s law of segregation . After the genetic crossing, the allele combinations are predicted which determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules. Since sickle-cell disease is an autosomal recessive disease, it shows its effect only in the homozygous recessive genotype.

Question

Want to see the full answer?

Answer 1

Question

Chapter 14, Problem 9TYU

Summary Introduction

To determine: The probability of birth of a child with sickle-cell disease, if both spouses are predicted to be carriers of recessive allele causing sickle-cell disease.

Concept introduction:

During gamete formation, two alleles of a gene segregate into different gametes. This is based on Mendel’s law of segregation. After the genetic crossing, the allele combinations are predicted which determine the genotype of the offspring. The occurrence of genotypes can be determined on the basis of probability rules. Since sickle-cell disease is an autosomal recessive disease, it shows its effect only in the homozygous recessive genotype.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Jan and Michael are both carriers for the cystic fibrosis allele. If Jan and Michael have five children, what the probability that three or more of the children will have the disease?

Karen and Steve each have a sibling with sickle-cell disease.Neither Karen nor Steve nor any of their parents have thedisease, and none of them have been tested to see if they carrythe sickle-cell allele. Based on this incomplete information,calculate the probability that if this couple has a child, thechild will have sickle-cell disease.

Mark has an autosomal recessive condition called sickle cell anemia, a serious blood disorder that is associated with painful complications. His spouse has not experienced symptoms of sickle cell anemia but their first child developed the disease. What conclusions can be drawn about the mother's genotype and the probability of having a second child with the condition? Answer Choices: A: her genotype is heterozygous and there is a 25% percent chance of having another child with the disorder B: her genotype is heterozygous and there is a 50% percent chance of having another child with the disorder C: her genotype is heterozygous and there is a 75% percent chance of having another child with the disorder D: she lacks the allele for sickle cell anemia in that she lacks symptoms of the disease. There is a 0% percent chance of having another child with the disorderMark has an autosomal recessive condition called sickle cell anemia, a serious blood disorder that is associated with…