Salicylic acid, HOC 6 H 4 CO 2 H , and its derivatives have been used as pain relievers for a long time. Salicylic acid occurs in small amounts in the leaves, bark, and roots of some vegetation (most notably historically in the bark of the willow tree). Extracts of these plants have been used as medications for centuries. The acid was first isolated in the laboratory in 1838. (a) Both functional groups of salicylic acid ionize in water, with K a = 1.0 × 10 − 3 for the − CO 2 H group and 4.2 × 10 - 13 for the - OH group. What is the pH of a saturated solution of the acid (solubility = 1.8 g/L). (b) Aspirin was discovered as a result of efforts to produce a derivative of salicylic acid that would not be irritating to the stomach lining. Aspirin is acetylsalicylic acid, CH 3 CO 2 C 6 H 4 CO 2 H . The − C O 2 H functional group is still present, but its acidity is reduced, K a =3 .0 10 -4 . What is the pH of a solution of aspirin with the same concentration as a saturated solution of salicylic acid (See Part a).
Salicylic acid, HOC 6 H 4 CO 2 H , and its derivatives have been used as pain relievers for a long time. Salicylic acid occurs in small amounts in the leaves, bark, and roots of some vegetation (most notably historically in the bark of the willow tree). Extracts of these plants have been used as medications for centuries. The acid was first isolated in the laboratory in 1838. (a) Both functional groups of salicylic acid ionize in water, with K a = 1.0 × 10 − 3 for the − CO 2 H group and 4.2 × 10 - 13 for the - OH group. What is the pH of a saturated solution of the acid (solubility = 1.8 g/L). (b) Aspirin was discovered as a result of efforts to produce a derivative of salicylic acid that would not be irritating to the stomach lining. Aspirin is acetylsalicylic acid, CH 3 CO 2 C 6 H 4 CO 2 H . The − C O 2 H functional group is still present, but its acidity is reduced, K a =3 .0 10 -4 . What is the pH of a solution of aspirin with the same concentration as a saturated solution of salicylic acid (See Part a).
Salicylic acid,
HOC
6
H
4
CO
2
H
, and its derivatives have been used as pain relievers for a long time. Salicylic acid occurs in small amounts in the leaves, bark, and roots of some vegetation (most notably historically in the bark of the willow tree). Extracts of these plants have been used as medications for centuries. The acid was first isolated in the laboratory in 1838.
(a) Both functional groups of salicylic acid ionize in water, with
K
a
=
1.0
×
10
−
3
for the
−
CO
2
H
group and
4.2
×
10
-
13
for the -OH group. What is the pH of a saturated solution of the acid (solubility = 1.8 g/L).
(b) Aspirin was discovered as a result of efforts to produce a derivative of salicylic acid that would not be irritating to the stomach lining. Aspirin is acetylsalicylic acid,
CH
3
CO
2
C
6
H
4
CO
2
H
.
The
−
C
O
2
H
functional group is still present, but its acidity is reduced,
K
a
=3
.0 10
-4
. What is the pH of a solution of aspirin with the same concentration as a saturated solution of salicylic acid (See Part a).
Definition Definition Group of atoms that shape the chemical characteristics of a molecule. The behavior of a functional group is uniform in undergoing comparable chemical reactions, regardless of the other constituents of the molecule. Functional groups aid in the classification and anticipation of reactivity of organic molecules.
Consider the reaction sequence below to answer the following questions:
EtO
Compound X
1. NaOEt, EtOH
OEt
Br
CO₂Et
NaOEt, EtOH
Compound Z
CO₂Et
Compound Y
A. Compound X, diethyl propanedioate, is more commonly known as
a. ethyl acetoacetate
b.
acetoacetic ester
C.
oxalic ester
d. malonic ester
3. Write the complete stepwise mechanism for the conversion of Compound X into Compound Y. Show
all electron flow with arrows and draw all intermediate structures.
Classify each of the following nitrogen atoms in the following compounds as primary, secondary,
tertiary, or quaternary [three only]
CH3
HO-CHCHNHCH3
A.
B.
C.
H&C CH3
D.
HO
phedrine
CH2CHCH3 amphetamine
NH₂
mepiquat chloride
faxofenadine
OH
H&C CH
CO₂H
Draw the structure of the aldol self-condensation product for each of the following compounds. If a
compound does not undergo aldol self-condensation, explain why it does not.
A.
B.
CHICHCH₂OH
CH3CHCH2CH
CH3
CH3
C.
CH 30
H3C-C-C-H
CH3
questions
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