Salicylic acid, HOC 6 H 4 CO 2 H , and its derivatives have been used as pain relievers for a long time. Salicylic acid occurs in small amounts in the leaves, bark, and roots of some vegetation (most notably historically in the bark of the willow tree). Extracts of these plants have been used as medications for centuries. The acid was first isolated in the laboratory in 1838. (a) Both functional groups of salicylic acid ionize in water, with K a = 1.0 × 10 − 3 for the − CO 2 H group and 4.2 × 10 - 13 for the - OH group. What is the pH of a saturated solution of the acid (solubility = 1.8 g/L). (b) Aspirin was discovered as a result of efforts to produce a derivative of salicylic acid that would not be irritating to the stomach lining. Aspirin is acetylsalicylic acid, CH 3 CO 2 C 6 H 4 CO 2 H . The − C O 2 H functional group is still present, but its acidity is reduced, K a =3 .0 10 -4 . What is the pH of a solution of aspirin with the same concentration as a saturated solution of salicylic acid (See Part a).
Salicylic acid, HOC 6 H 4 CO 2 H , and its derivatives have been used as pain relievers for a long time. Salicylic acid occurs in small amounts in the leaves, bark, and roots of some vegetation (most notably historically in the bark of the willow tree). Extracts of these plants have been used as medications for centuries. The acid was first isolated in the laboratory in 1838. (a) Both functional groups of salicylic acid ionize in water, with K a = 1.0 × 10 − 3 for the − CO 2 H group and 4.2 × 10 - 13 for the - OH group. What is the pH of a saturated solution of the acid (solubility = 1.8 g/L). (b) Aspirin was discovered as a result of efforts to produce a derivative of salicylic acid that would not be irritating to the stomach lining. Aspirin is acetylsalicylic acid, CH 3 CO 2 C 6 H 4 CO 2 H . The − C O 2 H functional group is still present, but its acidity is reduced, K a =3 .0 10 -4 . What is the pH of a solution of aspirin with the same concentration as a saturated solution of salicylic acid (See Part a).
Salicylic acid,
HOC
6
H
4
CO
2
H
, and its derivatives have been used as pain relievers for a long time. Salicylic acid occurs in small amounts in the leaves, bark, and roots of some vegetation (most notably historically in the bark of the willow tree). Extracts of these plants have been used as medications for centuries. The acid was first isolated in the laboratory in 1838.
(a) Both functional groups of salicylic acid ionize in water, with
K
a
=
1.0
×
10
−
3
for the
−
CO
2
H
group and
4.2
×
10
-
13
for the -OH group. What is the pH of a saturated solution of the acid (solubility = 1.8 g/L).
(b) Aspirin was discovered as a result of efforts to produce a derivative of salicylic acid that would not be irritating to the stomach lining. Aspirin is acetylsalicylic acid,
CH
3
CO
2
C
6
H
4
CO
2
H
.
The
−
C
O
2
H
functional group is still present, but its acidity is reduced,
K
a
=3
.0 10
-4
. What is the pH of a solution of aspirin with the same concentration as a saturated solution of salicylic acid (See Part a).
4. Provide a clear arrow-pushing mechanism for the following reactions. Do not skip proton
transfers, do not combine steps, and make sure your arrows are clear enough to be interpreted
without ambiguity.
a)
NHBoc
⚫OBn
HO.
H3C
CO2CH3
-OBn
H3C
H3C.
H3C.
NHBOC
CI
CO2CH3
Draw structures of the following compounds and identify their role:
mCPBA
(MCPBA)
DMS
Py
9-BBN
LAH
Sia₂BH
TsCI
PCC
t-BuOK
LDA
MeLi
n-BuLi
DMSO
DMF
Sodium Borohydride
Lithium DiisopropylAmide
2
Using Luther's rule, calculate the reference potential of the Hg2+/Hg redox electrode.
DATA: Electrode potentials E° = 0,854 V y E 0,788 V
Hg2+/Hg
2+
Hg2/Hg
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.