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Seeley's Anatomy & Physiology
12th Edition
ISBN: 9781260399127
Author: VanPutte, Cinnamon
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 14, Problem 3CT
Summary Introduction
To describe:
The possibility of the spinal cord damage of the right side because a patient is suffering from the loss of two-point discrimination and proprioception on the right side of the body.
Introduction:
Two-point discrimination (2PD) is the ability to determine that two similar skin-touching objects are two separate points, not one. During a neurological examination, it is often measured with two sharp points and is thought to show the finely innervated region of the skin.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 14 Solutions
Seeley's Anatomy & Physiology
Ch. 14.1 - In general, into what three groups con sensory...Ch. 14.1 - List the eight major types of sensory receptors,...Ch. 14.1 - Prob. 3AYPCh. 14.1 - Prob. 4AYPCh. 14.1 - Prob. 5AYPCh. 14.1 - Prob. 6AYPCh. 14.1 - Prob. 7AYPCh. 14.1 - How do descending pathways modulate sensation?Ch. 14.1 - How are pain sensations localized? What is...Ch. 14.1 - Prob. 10AYP
Ch. 14.1 - Describe the spatial organization of the general...Ch. 14.1 - Prob. 12AYPCh. 14.2 - Prob. 13AYPCh. 14.2 - Prob. 14AYPCh. 14.2 - Prob. 15AYPCh. 14.2 - Prob. 16AYPCh. 14.2 - What two tracts form the direct pathways? What...Ch. 14.2 - Describe the location of the neurons in each...Ch. 14.2 - Name the structures and tracts that form the...Ch. 14.2 - Prob. 20AYPCh. 14.2 - Prob. 21AYPCh. 14.2 - What are the three functional parts of the...Ch. 14.2 - Explain the comparator activities of the...Ch. 14.2 - What are the general symptoms of cerebellar...Ch. 14.3 - Prob. 25AYPCh. 14.3 - Prob. 26AYPCh. 14.3 - Discuss the somatic motor output and reflexes from...Ch. 14.3 - Prob. 28AYPCh. 14.3 - Prob. 29AYPCh. 14.4 - Prob. 30AYPCh. 14.4 - Prob. 31AYPCh. 14.4 - Prob. 32AYPCh. 14.4 - Prob. 33AYPCh. 14.4 - What conditions produce alpha, beta, theta. and...Ch. 14.4 - Prob. 35AYPCh. 14.4 - Prob. 36AYPCh. 14.4 - Prob. 37AYPCh. 14.4 - Distinguish between declarative and procedural...Ch. 14.4 - Prob. 39AYPCh. 14.4 - Prob. 40AYPCh. 14.5 - Prob. 41AYPCh. 14.5 - Prob. 42AYPCh. 14.5 - Does aging always produce memory loss?Ch. 14 - Prob. 1RACCh. 14 - Prob. 2RACCh. 14 - Prob. 3RACCh. 14 - Prob. 4RACCh. 14 - Prob. 5RACCh. 14 - Prob. 6RACCh. 14 - Prob. 7RACCh. 14 - Prob. 8RACCh. 14 - Tertiary neurons in both the spinothalamic tract...Ch. 14 - Prob. 10RACCh. 14 - Prob. 11RACCh. 14 - Prob. 12RACCh. 14 - Prob. 13RACCh. 14 - Prob. 14RACCh. 14 - Prob. 15RACCh. 14 - Prob. 16RACCh. 14 - Prob. 17RACCh. 14 - Prob. 18RACCh. 14 - Which of these pathways is not an indirect...Ch. 14 - Prob. 20RACCh. 14 - The major effect of the basal nuclei is a. to act...Ch. 14 - Which part of the cerebellum is correctly matched...Ch. 14 - Prob. 23RACCh. 14 - Prob. 24RACCh. 14 - Prob. 25RACCh. 14 - The main connection between the right and left...Ch. 14 - Prob. 27RACCh. 14 - Prob. 28RACCh. 14 - Prob. 29RACCh. 14 - Prob. 30RACCh. 14 - Describe all the sensations and perceptions...Ch. 14 - Prob. 2CTCh. 14 - Prob. 3CTCh. 14 - Prob. 4CTCh. 14 - Prob. 5CTCh. 14 - Prob. 6CTCh. 14 - Prob. 7CTCh. 14 - Prob. 8CTCh. 14 - Prob. 9CT
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