LooseLeaf for Human Anatomy
5th Edition
ISBN: 9781259285271
Author: Michael McKinley Dr., Valerie O'Loughlin, Elizabeth Pennefather-O'Brien
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 14, Problem 2WYL
Compare and contrast the meanings of afferent and efferent.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 14 Solutions
LooseLeaf for Human Anatomy
Ch. 14 - Together, what three functions do the CNS and PNS...Ch. 14 - Compare and contrast the meanings of afferent and...Ch. 14 - How do dendrites and axons differ in terms of...Ch. 14 - Prob. 4WYLCh. 14 - Prob. 5WYLCh. 14 - Prob. 6WYLCh. 14 - Prob. 7WYLCh. 14 - Prob. 8WYLCh. 14 - Prob. 9WYLCh. 14 - Prob. 10WYL
Ch. 14 - Prob. 11WYLCh. 14 - Prob. 12WYLCh. 14 - Prob. 13WYLCh. 14 - How is a diverging circuit different from a...Ch. 14 - Prob. 1MCh. 14 - Prob. 1MCCh. 14 - Neurons that have only two processes attached to...Ch. 14 - Prob. 3MCCh. 14 - Prob. 4MCCh. 14 - Prob. 5MCCh. 14 - Prob. 6MCCh. 14 - a. Neurolemmocyte b. Astrocyte c. Neuron d....Ch. 14 - Which type of neuronal pool uses nerve impulse...Ch. 14 - Prob. 9MCCh. 14 - Prob. 10MCCh. 14 - What are the three structural types of neurons?...Ch. 14 - Prob. 2CRCh. 14 - Prob. 3CRCh. 14 - Prob. 4CRCh. 14 - Prob. 5CRCh. 14 - Describe the arrangement and structure of the...Ch. 14 - Prob. 7CRCh. 14 - What are the differences between electrical and...Ch. 14 - Discuss the similarities and differences between...Ch. 14 - What are the basic developmental events that occur...Ch. 14 - Prob. 1DCRCh. 14 - Prob. 2DCR
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