BIOLOGY: ESSENTIALS >LL< W/ CONNECT
BIOLOGY: ESSENTIALS >LL< W/ CONNECT
3rd Edition
ISBN: 9781260635379
Author: Hoefnagels
Publisher: MCG
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Chapter 14, Problem 2WIO

What type of reproductive barrier applies to each of these scenarios?

a. Humans introduced apple trees to North America in 1800s. Insects called hawthorn flies, which feed and mate on hawthorn plants, quickly discovered the new fruits. Some flies preferred the taste of apples to their native host plants. Because these flies mate where they eat, this difference in food preference quickly led to a reproductive barrier.
b Water buffalo and cattle can mate with each other, but the embryos die early in development.
c. Scientists try to mate two species of dragonfly that inhabit the same pond at the same time of day. However, females never allow males of the other species to mate with them.
d One species of reed warbler is active in the upper parts of the tree canopy while another species of reed warbler is active in the lower canopy. Both species are active during the day.
e. Scientists mate two parrots from different populations to see if speciation has occurred. The parrots mate over and over again, but the male’s sperm never fertilizes the female egg.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data  (b) k, ka, B1, and AUC* for the po data  (c) k, ka, B1, and AUC* for the ip data  (d) relative bioavailability for po vs ip, Fpo/Fip  (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip    MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0  Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present.  Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
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