Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
7th Edition
ISBN: 9781464126116
Author: David L. Nelson, Michael M. Cox
Publisher: W. H. Freeman
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Chapter 14, Problem 28P
Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer
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Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

SuccinateFumerateMalateOxaloacetatePEPcarboxykinasePhosphoenolpyruvateGlucose

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