The transformation of succinate into glucose and its stoichiometry. Introduction: A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

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Answer 1

Question

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

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Answer 2

Question

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

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Answer 3

Question

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

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Answer 4

Question

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

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Answer 5

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

Answer 6

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

Answer 7

Chapter 14, Problem 28P

Summary Introduction

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Answer 8

Expert Solution & Answer

Explanation of Solution

Explanation:

Phloridzin blocks the reabsorption of glucose in the tubules of kidney which allows excretion of glucose in urine. The ingested succinate can be converted into glucose through the process of gluconeogenesis.

Succinate is first converted into oxaloacetate through series of reactions. Then the oxaloacetate is transported into cytosol for its conversion into phosphoenolpyruvate by enzyme, PEP carboxykinase. In the cytosol, PEP is converted into glucose through gluconeogenesis.

The mechanism (stoichiometry) of the reaction is as follows:

Succinate→Fumerate→Malate→Oxaloacetate→PEP carboxykinasePhosphoenolpyruvate ↓ ↓ Glucose

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Ch. 14 - Prob. 1P Ch. 14 - Prob. 2P Ch. 14 - Prob. 3P Ch. 14 - Prob. 4P Ch. 14 - Prob. 5P Ch. 14 - Prob. 6P Ch. 14 - Prob. 7P Ch. 14 - Prob. 8P Ch. 14 - Prob. 9P Ch. 14 - Prob. 10P

The transformation of succinate into glucose and its stoichiometry. Introduction: A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Concept explainers

Videos

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Explanation of Solution

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Chapter 14 Solutions

The transformation of succinate into glucose and its stoichiometry. Introduction: A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Concept explainers

Videos

To determine: The transformation of succinate into glucose and its stoichiometry. Introduction: A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.

Explanation of Solution

Want to see more full solutions like this?

Chapter 14 Solutions

To determine: The transformation of succinate into glucose and its stoichiometry.

Introduction:

A toxic glycoside, phloridzin obtained from the bark of pear tree blocks the glucose absorption form kidney tubules and cause the blood glucose to be excreted in urine.