ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Chapter 1.4, Problem 1WDT
Summary Introduction
To explain: The type of metabolic reactions that are utilized primarily: anabolic or catabolic
Concept introduction:
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 1 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 1.1 -
LEARNING OBJECTIVES
1. Describe the science of...Ch. 1.1 -
LEARNING OBJECTIVES
2. List the subdivisions in...Ch. 1.1 - WHAT DID YOU LEARN?
1 How might knowledge of...Ch. 1.1 -
LEARNING OBJECTIVES
3. Describe the science of...Ch. 1.1 -
LEARNING OBJECTIVES
4. List the subdivisions in...Ch. 1.1 - What is the relationship between anatomy and...Ch. 1.1 - __________ physiology examines how the heart,...Ch. 1.2 - Prob. 5LOCh. 1.2 - Compare and contrast how anatomists and...Ch. 1.4 - Prob. 7LO
Ch. 1.4 - WHAT DO YOU THINK?
1 When you digest a meal,...Ch. 1.4 - Prob. 6WDLCh. 1.4 - Prob. 8LOCh. 1.4 - Prob. 7WDLCh. 1.4 - LEARNING OBJECTIVE
9. Compare the organ systems of...Ch. 1.4 - Prob. 8WDLCh. 1.5 - LEARNING OBJECTIVE
10. Describe the anatomic...Ch. 1.5 - Prob. 11LOCh. 1.5 - What type of plane would separate the nose and...Ch. 1.5 - LEARNING OBJECTIVE
12. Define the different...Ch. 1.5 - Which directional term would be most appropriate...Ch. 1.5 - The term antebrachial refers to which body region?Ch. 1.5 - LEARNING OBJECTIVES
14. Describe the body cavities...Ch. 1.5 - Prob. 15LOCh. 1.5 - Prob. 2WDTCh. 1.5 - Which body cavity is associated with the lungs,...Ch. 1.5 - Prob. 16LOCh. 1.5 - If a physician makes an incision into the abdomen...Ch. 1.6 - Prob. 17LOCh. 1.6 - List and describe the three components of a...Ch. 1.6 - Prob. 19LOCh. 1.6 - Prob. 20LOCh. 1.6 - Prob. 15WDLCh. 1.6 - Prob. 21LOCh. 1.6 - Prob. 22LOCh. 1.6 - Prob. 16WDLCh. 1.7 - LEARNING OBJECTIVE
23. Explain the general...Ch. 1.7 - What is an example of a disease process by which...Ch. 1 - Examining the superficial anatomic markings and...Ch. 1 - The __________ level of organization is composed...Ch. 1 - The term __________ refers to the sum of all...Ch. 1 - A midsagittal plane separates the body into a....Ch. 1 - The term used to describe an appendage structure...Ch. 1 - The __________ region is the anterior part of the...Ch. 1 - Prob. 7DYBCh. 1 - The __________ is the serous membrane layer that...Ch. 1 - The state of maintaining a constant internal...Ch. 1 - Prob. 10DYBCh. 1 - What are the similarities and differences between...Ch. 1 - List the levels of organization in a human,...Ch. 1 - Prob. 13DYBCh. 1 - Do You Know the Basics?
14. Name the eleven organ...Ch. 1 - Describe the body in the anatomic position. Why is...Ch. 1 - Prob. 16DYBCh. 1 - What are the two body cavities within the...Ch. 1 - Describe the structure and function of serous...Ch. 1 - What are the main components in a homeostatic...Ch. 1 - Prob. 20DYBCh. 1 - Your friend Eric complains of some pain in his...Ch. 1 - Prob. 2CALCh. 1 - Your friend Eric complains of some pain in his...Ch. 1 - When you are outside on a hot, humid day, what...Ch. 1 - A friend just started taking Zoloft (an SSRI) and...Ch. 1 - Lynn was knocked off her bicycle during a race....Ch. 1 - Prob. 2CSLCh. 1 - Prob. 3CSL
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