The one-gene, one-enzyme hypothesis. Introduction: Genes are sets of nucleotides that codes for a particular protein. The genes have to be expressed for the synthesis of a protein. This gene expression is regulated depending on the requirement of the cell. For example, cell division proteins are synthesized prior to the cell division. Prokaryotic and eukaryotic genes have differential gene expression in order to suit the specific needs of the cell.

Question

. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid is located on the outside of the soluble protein but not near an active site. O-H¨ A. What type of mutation occurred? O-H B. What 2 types of chemical bonds are found in the R-groups of each amino acid? The R groups are shaded. CH2 CH2 CH2 H2N-C-COOH H2N-C-COOH 1 H Glutamic acid H Aspartic acid C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules? D. Consider the chemical properties of the two amino acids and the location of the amino acid in the protein. Explain what effect this mutation will have on this protein's function and why.

Answer 1

Question

Chapter 13.1, Problem 1C

Summary Introduction

To explain: The one-gene, one-enzyme hypothesis.

Introduction: Genes are sets of nucleotides that codes for a particular protein. The genes have to be expressed for the synthesis of a protein. This gene expression is regulated depending on the requirement of the cell. For example, cell division proteins are synthesized prior to the cell division. Prokaryotic and eukaryotic genes have differential gene expression in order to suit the specific needs of the cell.

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. Consider a base substitution mutation that occurred in a DNA sequence that resulted in a change in the encoded protein from the amino acid glutamic acid to aspartic acid. Normally the glutamic acid amino acid is located on the outside of the soluble protein but not near an active site. O-H¨ A. What type of mutation occurred? O-H B. What 2 types of chemical bonds are found in the R-groups of each amino acid? The R groups are shaded. CH2 CH2 CH2 H2N-C-COOH H2N-C-COOH 1 H Glutamic acid H Aspartic acid C. What 2 types of bonds could each R-group of each of these amino acids form with other molecules? D. Consider the chemical properties of the two amino acids and the location of the amino acid in the protein. Explain what effect this mutation will have on this protein's function and why.

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