6th Edition

ISBN: 9781259700903

Author: Leland Hartwell Dr., Michael L. Goldberg Professor Dr., Janice Fischer, Leroy Hood Dr.

Publisher: McGraw-Hill Education

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The technique of linking biological information to genome sequences is termed genome annotation. Gene annotation is the method of identifying gene locations and coding sections. It helps us understand what these genes are doing in the body through establ…

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Textbook Question

Chapter 13, Problem 7P

The two graphs that follow represent genomic sequencing data for two fruit flies with scarlet-colored eyes. Each fly is a heterozygote for a chromosome 3 with normal gene order and a recessive scarlet (st) mutation, and a rearranged chromosome 3; the rearrangements are different in the two flies. Each circle on the graph indicates the number of sequence reads (y coordinate) obtained for a 100 bp sequence starting at the position on chromosome 3 that is shown by the x coordinate.

Chapter 13, Problem 7P, The two graphs that follow represent genomic sequencing data for two fruit flies with

a.	What is the nature of the rearranged chromosome in each fly? What are the approximate locations of the breakpoints defining these rearrangements? How could you find the exact nucleotides at the breakpoints?
b.	Can you conclude that at least part of the st gene lies in a particular region of chromosome 3? If so, give the coordinates of that region defined as precisely as possible.
c.	Is it possible that one or more protein-coding exons of the st gene lie outside of the region you defined in part (b)? Explain.
d.	Does your ability to map the st gene on the basis of these data reflect a recombination experiment or a complementation experiment?

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Chapter 13, Problem 6P

Chapter 13, Problem 8P

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Chapter 13 Solutions

Genetics: From Genes to Genomes

Ch. 13 - For each of the terms in the left column, choose...Ch. 13 - Prob. 2P Ch. 13 - For each of the following types of chromosomal...Ch. 13 - For the following types of chromosomal...Ch. 13 - One of the X chromosomes in a particular...Ch. 13 - A diploid strain of yeast was made by mating a...Ch. 13 - The two graphs that follow represent genomic...Ch. 13 - A series of chromosomal mutations in Drosophila...Ch. 13 - Indicate which of the four major classes of...Ch. 13 - The recessive, X-linked z1 mutation of the...

Ch. 13 - Genes a and b are 21 m.u. apart when mapped in...Ch. 13 - In the following group of figures, the pink lines...Ch. 13 - Three strains of Drosophila Bravo, X-ray, and...Ch. 13 - Two yeast strains were mated and sporulated...Ch. 13 - Suppose a haploid yeast strain carrying two...Ch. 13 - In the mating between two haploid yeast strains...Ch. 13 - During ascus formation in Neurospora, any...Ch. 13 - In the following figure, black and pink lines...Ch. 13 - In Drosophila, the gene for cinnabar eye color is...Ch. 13 - Semisterility in corn, as seen by unfilled ears...Ch. 13 - A promising biological method for insect control...Ch. 13 - Prob. 23P Ch. 13 - a. Among the progeny of a self-fertilized...Ch. 13 - Duchenne muscular dystrophy DMD is caused by a...Ch. 13 - WHIM syndrome is a disease of the immune system...Ch. 13 - Explain how transposable elements can cause the...Ch. 13 - The Drosophila genome normally harbors about 40 P...Ch. 13 - Drosophila P elements were discovered because of a...Ch. 13 - Flies homozygous for mutant alleles of a...Ch. 13 - Fred and Mary have a child named Bob. The genomic...Ch. 13 - Uniparental disomy is a rare phenomenon in which...Ch. 13 - Among adults with Turner syndrome, it has been...Ch. 13 - In Neurospora, his2 mutants require the amino acid...Ch. 13 - Human geneticists interested in the effects of...Ch. 13 - The incidence of Down syndrome will be very high...Ch. 13 - The Drosophila chromosome 4 is extremely small;...Ch. 13 - Down syndrome is usually caused by having a...Ch. 13 - Common red clover, Trifolium pratense, is a...Ch. 13 - The numbers of chromosomes in the somatic cells of...Ch. 13 - Prob. 41P Ch. 13 - Somatic cells in organisms of a particular diploid...Ch. 13 - An allotetraploid species has a genome composed of...Ch. 13 - Prob. 44P Ch. 13 - Chromosomes normally associate during meiosis I as...Ch. 13 - Using whole-genome sequencing, how could you...Ch. 13 - Prob. 47P Ch. 13 - Prob. 48P Ch. 13 - Seedless watermelons that you find in the...Ch. 13 - The names of hybrid animals are usually themselves...Ch. 13 - While most animals cannot tolerate polyploidy,...Ch. 13 - What characteristic property of translocations...Ch. 13 - Prob. 53P Ch. 13 - In the accompanying figure, the top and bottom...Ch. 13 - Prob. 55P Ch. 13 - The accompanying figure shows idiograms of human...Ch. 13 - Prob. 57P

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Solution Summary: The author explains the nature of the rearranged chromosomes in fruit flies and the way to detect the extra nucleotides at the breakpoints.

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Chapter 13 Solutions