To answer: The factors that are essential for the normal production of red blood cells. Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

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Answer 1

Question

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

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Kinetics: One-Compartment First-Order Absorption 1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration. Using this data and set of graphs, determine:(calculate for each variable) (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e)absolute ip bioavailability, Fip (f) absolute po bioavailability, Fpo

3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug: (a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate) (b) Estimate the time for maximum plasma concentration (tmax). (c) Estimate the maximum plasma concentration (Cmax). (d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.) (e)…

Answer 2

Question

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

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Answer 3

Question

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

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Answer 4

Question

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

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Answer 5

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

Answer 6

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

Answer 7

Chapter 13, Problem 1KQ

Summary Introduction

To answer: The factors that are essential for the normal production of red blood cells.

Introduction: Blood is an essential body fluid, which is the primary transport system of the body. It is involved in both pathological and physiological activities of all organs. The red blood cells or erythrocytes are one of the major components of the blood. It is necessary for the transportation of oxygen within the circulatory system. It possesses hemoglobin molecules that efficiently move oxygen from the lungs to other parts of the body.

Answer 8

Expert Solution & Answer

Explanation of Solution

The factors that are essential for the normal production of red blood cells are as follows:

Dietary sources: Dietary sources such as vitamins (especially folate, riboflavin, B12, B6, ascorbic acid, pantothenic acid, and vitamin E), protein, iron, and minerals.

Intrinsic factors: The intrinsic factors are required for the absorption of vitamin B12 in the ileum.

Erythropoietin: It is required for stimulating the red blood cell production.

Functional bone marrow: The bone marrow should be functional for the production of erythrocytes.

Answer 9

Expert Solution & Answer

Answer 10

Expert Solution & Answer

Answer 11

Ch. 13 - Prob. 1KQ Ch. 13 - Prob. 2KQ Ch. 13 - Prob. 3KQ Ch. 13 - Prob. 4KQ Ch. 13 - Prob. 5KQ Ch. 13 - Prob. 6KQ Ch. 13 - Prob. 7KQ

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Chapter 13 Solutions