To label: To label the diagram of the antibody. Introduction: The structure of the antibody resembles the alphabet Y and consists of 4 proteins (2 light chains and 2 heavy chains). Pictorial representation: Figure: The structure of an antibody molecule. The correct answers are: Antigen binding sites Light chain Heavy chain V stands for the variable region C stands for the constant region Explanation for the answers: Antigen binding site − These are the sites on the amino-terminal end of both light and heavy chain. It provides a site of attachment for the antigen. Light chain − There is 2 identical light chains consisting of polypeptides. They are bound to the heavy chain via disulfide bonds and non-covalent interactions. Heavy chain − There are 5 types of heavy chains (accordingly antibodies are named) and attached to each other via the disulfide bonds. V stands for variable region. The amino-terminal end of both heavy and light chain of about 100-110 amino acids vary considerably among antibodies and hence are called as variable region. C stands for the constant region. The carboxy-terminalend of both light and heavy chain shows similarity among antibodies and hence is considered as constant regions.

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Chapter 13, Problem 13A

Summary Introduction

To label:

To label the diagram of the antibody.

Introduction:

The structure of the antibody resembles the alphabet Y and consists of 4 proteins (2 light chains and 2 heavy chains).

Pictorial representation:

Figure: The structure of an antibody molecule.

The correct answers are:

Antigen binding sites

Light chain

Heavy chain

V stands for the variable region

C stands for the constant region

Explanation for the answers:

Antigen binding site − These are the sites on the amino-terminal end of both light and heavy chain. It provides a site of attachment for the antigen.

Light chain − There is 2 identical light chains consisting of polypeptides. They are bound to the heavy chain via disulfide bonds and non-covalent interactions.

Heavy chain − There are 5 types of heavy chains (accordingly antibodies are named) and attached to each other via the disulfide bonds.

V stands for variable region. The amino-terminal end of both heavy and light chain of about 100-110 amino acids vary considerably among antibodies and hence are called as variable region.

C stands for the constant region. The carboxy-terminalend of both light and heavy chain shows similarity among antibodies and hence is considered as constant regions.

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