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(a)
Interpretation:
To obtain the desired product, the reactant molecule must undergo a Grignard reaction and needs a protecting group to facilitate the reaction to occur. The protecting reagent is to be determined.
Concept Introduction:
Normally, an aryl bromide can directly be converted to arylmagnesium halide by reaction with Magnesium. But in this case, there is the presence of an acidic alcoholic group which can hinder the formation of Grignard reagent, which is a strong base. To prevent this, an
After the formation of the Grignard reagent, it can be coupled with a suitable reactant, followed by deprotection, to obtain the final product.
(b)
Interpretation:
To obtain the desired product, the reactant molecule has to undergo a Grignard reaction and needs a protecting group to facilitate the reaction to occur. The protecting group is to be determined.
Concept Introduction:
Normally, an aryl bromide can directly be converted to arylmagnesium halide by reaction with Magnesium. But in this case, there is the presence of an acidic alcoholic group which can hinder the formation of Grignard reagent, which is a strong base. To prevent this, an
After the formation of the Grignard reagent, it can be coupled with a suitable reactant, followed by deprotection, to obtain the final product.
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Chapter 12 Solutions
ORGANIC CHEMISTRY-PRINT COMPANION (LL)
- Identify the missing organic reactants in the following reaction: X + Y H+ two steps Note: This chemical equation only focuses on the important organic molecules in the reaction. Additional inorganic or small-molecule reactants or products (like H2O) are not shown. In the drawing area below, draw the skeletal ("line") structures of the missing organic reactants X and Y. You may draw the structures in any arrangement that you like, so long as they aren't touching. Click and drag to start drawing a structure. Х :arrow_forwardDraw the mechanism of friedel-crafts acylation using acetyl chloride of m-Xylenearrow_forwardI need help naming these in IUPACarrow_forward
- H R Part: 1/2 :CI: is a/an electrophile Part 2 of 2 Draw the skeletal structure of the product(s) for the Lewis acid-base reaction. Include lone pairs and formal charges (if applicable) on the structures. 4-7: H ö- H Skip Part Check X :C1: $ % L Fi Click and drag to start drawing a structure. MacBook Pro & ㅁ x G 0: P Add or increase positive formal cha Save For Later Submit ©2025 McGraw Hill LLC. All Rights Reserved. Terms of Use | Privacy Centearrow_forwardDraw the friedel-crafts acylation mechanism of m-Xylenearrow_forwardDon't used hand raiting and don't used Ai solutionarrow_forward
- 1. Base on this experimental results, how do you know that the product which you are turning in is methyl 3-nitrobenzoate(meta substituted product ) rather than either of the other two products? 2. What observation suggests that at least a small amount of one or both of the other two isomers are in the mother liquor?arrow_forwardExplain Huckel's rule.arrow_forwardhere is my question can u help me please!arrow_forward
- Organic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning
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