LIFE:SCIENCE OF BIOL.(LL) >CUSTOM<
LIFE:SCIENCE OF BIOL.(LL) >CUSTOM<
11th Edition
ISBN: 9781319209957
Author: Sadava
Publisher: MAC HIGHER
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Chapter 12.4, Problem 6R
Summary Introduction

To review:

The linked genes from the data and the distance between them in map units.

Introduction:

Linked genes are those, which get inherited together and do not follow the normal Mendelian inheritance pattern. These genes have the short distance in them in map units, thereby they get inherited as a unit and they do not segregate separately.

The cross results of three autosomal characteristics in Drosophila, namely, the body color, wings shape, and eye color are as follows:

Cross I:

Parents: Heterozygous red eye color, normal wings × sepia eye color, vestigial wings.

Offspring results:

131 Red-eye color, Normal wings
120 Sepia eye color, Vestigial wings
122 Red-eye color, Vestigial wings
127 Sepia eye color, Normal wings

Cross II:

Parents: Heterozygous gray body, normal wings × black body color, vestigial wings.

Offspring results:

236 Gray body, normal wings.
253 Black body, Vestigial wings.
50 Gray body, Vestigial wings.
61 Black body, Normal wings.

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Students have asked these similar questions
You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
You implant an FGF10-coated bead into the anterior flank of a chicken embryo, directly below the level of the wing bud. What is the phenotype of the resulting ectopic limb?  Briefly describe the expected expression domains of 1) Shh, 2) Tbx4, and 3) Tbx5 in the resulting ectopic limb bud.
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