Inquiry into Life
16th Edition
ISBN: 9781260482638
Author: Mader, Sylvia
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Textbook Question
Chapter 12.4, Problem 2CYP
Name the major blood vessels through which blood flows to the lungs and other parts of the body.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 12 Solutions
Inquiry into Life
Ch. 12.1 - Prob. 1LOCh. 12.1 - Explain the process of capillary exchange.Ch. 12.1 - Prob. 1CYPCh. 12.1 - Prob. 2CYPCh. 12.2 - Prob. 1LOCh. 12.2 - Prob. 2LOCh. 12.2 - 3. Define capillary exchange, and describe the...Ch. 12.2 - Prob. 1QTCCh. 12.2 - Prob. 2QTCCh. 12.2 - Prob. 3QTC
Ch. 12.2 - Prob. 1CYPCh. 12.2 - Prob. 2CYPCh. 12.2 - Identify some types of diseases that would be...Ch. 12.2 - Prob. 4CYPCh. 12.3 - Identify the major components of the heart,...Ch. 12.3 - Prob. 2LOCh. 12.3 - Describe the intrinsic and extrinsic control of...Ch. 12.3 - Prob. 1CYPCh. 12.3 - Prob. 2CYPCh. 12.3 - Prob. 3CYPCh. 12.3 - Prob. 4CYPCh. 12.4 - Prob. 1LOCh. 12.4 - Prob. 2LOCh. 12.4 - Prob. 1CYPCh. 12.4 - Name the major blood vessels through which blood...Ch. 12.4 - Prob. 3CYPCh. 12.5 - Describe the major categories of cardiovascular...Ch. 12.5 - Define hypertension and explain its most common...Ch. 12.5 - Prob. 3LOCh. 12.5 - Review the risk factors discussed in this reading....Ch. 12.5 - Prob. 2QTCCh. 12.5 - Prob. 3QTCCh. 12.5 - Prob. 1CYPCh. 12.5 - Prob. 2CYPCh. 12.5 - Prob. 3CYPCh. 12 - Prob. S4.2BYBCh. 12 - Prob. S11.1BYBCh. 12 - Section 11.5 The cardiovascular system interacts...Ch. 12 - Prob. 1ACh. 12 - Prob. 2ACh. 12 - Prob. 3ACh. 12 - Prob. 4ACh. 12 - Prob. 5ACh. 12 - Prob. 6ACh. 12 - Prob. 7ACh. 12 - Prob. 8ACh. 12 - Prob. 9ACh. 12 - An electrocardiogram measures
chemical signals...Ch. 12 - Prob. 11ACh. 12 - Prob. 12ACh. 12 - In which of the following does a blood vessel...Ch. 12 - Prob. 14ACh. 12 - Prob. 1TCCh. 12 - Prob. 2TCCh. 12 - Prob. 3TCCh. 12 - There are not enough living heats available to...
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