(A) To write: Describe the ligand for the NK-cell receptor CD94: NKG2A. Introduction: The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

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Answer 1

Question

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

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Answer 2

Question

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

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Answer 3

Question

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

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Answer 4

Question

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

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Answer 5

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 6

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 7

Chapter 12, Problem 15Q

Summary Introduction

(A)

To write:

Describe the ligand for the NK-cell receptor CD94: NKG2A.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 8

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 9

Summary Introduction

(B)

To write:

The concentration of this ligand on the target cell an effective measure of the presence or absence of classical MHC class I molecules.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 10

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 11

Summary Introduction

(C)

To write:

The Reason, this ligand considered a broad mechanism for the NK-cell detection of unhealthy cells that is relatively insensitive to MHC class I polymorphisms.

Introduction:

The activation of NK cells is conducted by the expression of different activating as well as, inhibitory receptors in a manner, which prevents the NK cells from attacking the normal cells. CD94: NKG2A complex develops inhibitory signals due to the presence of immunoreceptor tyrosine-based inhibitory motives (ITIM) in the cytoplasmic tail of NKG2A, enable recruitment of tyrosine phosphatase SHP-1, SHP-2, or SHIP that inactivate signaling cascade of NK-cell activation.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 12 - Prob. 1Q Ch. 12 - Prob. 2Q Ch. 12 - Prob. 3Q Ch. 12 - Prob. 4Q Ch. 12 - Prob. 5Q Ch. 12 - Prob. 6Q Ch. 12 - Prob. 7Q Ch. 12 - Prob. 8Q Ch. 12 - Prob. 9Q Ch. 12 - Prob. 10Q

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