PRINCIPLES OF LIFE:DIGITAL...-ACCESS
3rd Edition
ISBN: 9781319450366
Author: HILLIS
Publisher: MAC HIGHER
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Chapter 12, Problem 1.3Q
Summary Introduction
To determine: The average length of open reading frames (ORFs) in the random noncoding sequences of DNA.
Introduction: The noncoding sequences of DNA are elements of the DNA of an organism that do not encode the sequences of proteins. The noncoding DNA serves as a scaffold attachment regions. The function of noncoding DNA includes reassembly of transposons and the production of small RNA. Some noncoding DNA acts as a source of new exons. Around 98% of the total DNA is noncoding DNA in eukaryotes.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 12 Solutions
PRINCIPLES OF LIFE:DIGITAL...-ACCESS
Ch. 12.1 - Prob. 1LOCh. 12.1 - Prob. 2LOCh. 12.1 - Prob. 3LOCh. 12.1 - Prob. 4LOCh. 12.1 - Prob. 1FQCh. 12.1 - Prob. 2FQCh. 12.1 - Prob. 3FQCh. 12.1 - Prob. 1RACh. 12.1 - Prob. 2RACh. 12.1 - Prob. 3RA
Ch. 12.2 - Prob. 1LOCh. 12.2 - Prob. 2LOCh. 12.2 - Prob. 3LOCh. 12.2 - Prob. 4LOCh. 12.2 - Prob. 5LOCh. 12.2 - Prob. 1RACh. 12.2 - Prob. 2RACh. 12.2 - Prob. 3RACh. 12.2 - Prob. 4RACh. 12.2 - Prob. 1TKCh. 12.2 - Prob. 3TKCh. 12.3 - Prob. 1LOCh. 12.3 - Prob. 2LOCh. 12.3 - Prob. 3LOCh. 12.3 - Prob. 1RACh. 12.3 - Prob. 2RACh. 12.3 - Prob. 3RACh. 12.4 - Prob. 1LOCh. 12.4 - Prob. 2LOCh. 12.4 - Prob. 3LOCh. 12.4 - Prob. 4LOCh. 12.4 - Prob. 5LOCh. 12.4 - Prob. 1ICh. 12.4 - Prob. 2ICh. 12.4 - Prob. 3ICh. 12.4 - Prob. 1RACh. 12.4 - Prob. 2RACh. 12.4 - Prob. 3RACh. 12 - Prob. 1.1QCh. 12 - Prob. 1.2QCh. 12 - Prob. 1.3QCh. 12 - Prob. 2.1QCh. 12 - Prob. 2.2QCh. 12 - Prob. 2.3QCh. 12 - Prob. 3.1QCh. 12 - Prob. 3.2QCh. 12 - Prob. 3.3QCh. 12 - Prob. 4.1QCh. 12 - Prob. 4.2QCh. 12 - Prob. 4.3Q
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