EBK LIFE: THE SCIENCE OF BIOLOGY
EBK LIFE: THE SCIENCE OF BIOLOGY
11th Edition
ISBN: 8220103935432
Author: Sadava
Publisher: MAC HIGHER
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Chapter 11.7, Problem 2R
Summary Introduction

To review:

The comparison of tumor suppressors and oncogenes products in the cell cycle of normal and cancerous cells.

Introduction:

The function of tumor-suppressor genes is to suppress the proliferation of tumors. These genes products usually take part in the cell cycle. They perform the function of checkpoints in the cell cycle and do not allow the replication, cell division of damaged deoxyribonucleic acid (DNA) in the cells. Oncogenes are the potential genes that could transform into a cancer-causing gene. The reason lies in the fact because these genes usually concern themselves with the rate of cell growth.

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You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?
You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.
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