BIOLOGY >PRINT UPGRADE<
11th Edition
ISBN: 9780357091586
Author: Solomon
Publisher: CENGAGE L
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Chapter 11.4, Problem 4C
Summary Introduction
To explain: The way in which concept of norm of reaction is related to the lack of yellow hydrangea flowers.
Introduction: Norm of a reaction is defined as the single genotype that gives rise to range of possibilities under different environmental conditions. Norm of a reaction can be limited or broad.
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Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 11 Solutions
BIOLOGY >PRINT UPGRADE<
Ch. 11.1 - Define the terms phenotype, genotype, locus,...Ch. 11.1 - Describe Mendels principles of segregation and...Ch. 11.1 - Distinguish among monohybrid, dihybrid, and test...Ch. 11.1 - Explain Mendels principles of segregation and...Ch. 11.1 - What is the maximum number of different alleles...Ch. 11.1 - Can Mendels principle of segregation be...Ch. 11.1 - Prob. 3CCh. 11.2 - PREDICT Use the rules of probability to answer the...Ch. 11.2 - In answering the previous question, did you use...Ch. 11.3 - Define linkage and relate it to specific events in...
Ch. 11.3 - Show how data from a two-point test cross can be...Ch. 11.3 - Discuss the genetic determination of sex and the...Ch. 11.3 - What ratio of genotypes to phenotypes is observed...Ch. 11.3 - Prob. 2CCh. 11.3 - CONNECT Two loci exhibit 5% recombination between...Ch. 11.3 - Which chromosome determines the male sex in humans...Ch. 11.3 - Prob. 5CCh. 11.4 - Explain some of the ways genes may interact to...Ch. 11.4 - Distinguish among incomplete dominance,...Ch. 11.4 - Prob. 11LOCh. 11.4 - Prob. 1CCh. 11.4 - What is the difference between multiple alleles...Ch. 11.4 - Prob. 3CCh. 11.4 - Prob. 4CCh. 11 - One of the autosomal loci controlling eye color in...Ch. 11 - The F1 flies described in question 1 were mated...Ch. 11 - The type of cross described in question 2 is (a)...Ch. 11 - Individuals of genotype AaBb were crossed with...Ch. 11 - Assume that the ratio of females to males is 1:1....Ch. 11 - Redgreen color blindness is an X-linked recessive...Ch. 11 - When two long-winged flies were mated, the...Ch. 11 - The long hair of Persian cats is recessive to the...Ch. 11 - Mr. and Mrs. Smith are concerned because their own...Ch. 11 - A walnut comb rooster is mated to three hens. Hen...Ch. 11 - Individuals of genotype AaBb were mated to...Ch. 11 - Genes A and B are 6 map units apart, and A and C...Ch. 11 - VISUALIZE Sketch a series of diagrams showing each...Ch. 11 - Can you always ascertain an organisms genotype for...Ch. 11 - CONNECT Compare the mechanisms of genetic...Ch. 11 - EVOLUTION LINK Darwins theory of evolution by...Ch. 11 - INTERPRET DATA Using the graph in Figure 11-20,...
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