An approach to crystallize G protein to reveal the structure of the receptor during active signaling. Introduction: G proteins (guanine nucleotide -binding proteins) are membrane proteins that regulate signal transduction in cells. G protein-coupled receptors (GPCRs) in the cell membrane bind to the signaling molecules and activate G proteins. They regulate various essential cellular processes, intracellular signaling responses, and signal transmission from neurotransmitters, hormones, and other factors.

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Chapter 11.2, Problem 4CC

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To identify: An approach to crystallize G protein to reveal the structure of the receptor during active signaling.

Introduction:

G proteins (guanine nucleotide-binding proteins) are membrane proteins that regulate signal transduction in cells. G protein-coupled receptors (GPCRs) in the cell membrane bind to the signaling molecules and activate G proteins. They regulate various essential cellular processes, intracellular signaling responses, and signal transmission from neurotransmitters, hormones, and other factors.

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