HUMAN ANATOMY W/ACCESS
6th Edition
ISBN: 9781260929539
Author: SALADIN
Publisher: MCG
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Chapter 1.1, Problem 4BYGO
Anwer the following questions to test your understanding of the preceding section:
4. What are some reasons that sonography would be unsuitable for examining the size and location of a brain tumor?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
SHOW ALL WORK, including equation used, variables used and each step to your solution.
2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 1 Solutions
HUMAN ANATOMY W/ACCESS
Ch. 1.1 - The concept of MRI was conceived in 1948 but could...Ch. 1.1 - Prob. 2AWYKCh. 1.1 - Answer the following questions to test your...Ch. 1.1 - Anwer the following questions to test your...Ch. 1.1 - Anwer the following questions to test your...Ch. 1.1 - Anwer the following questions to test your...Ch. 1.2 - Anwer the following questions to test your...Ch. 1.2 - Anwer the following questions to test your...Ch. 1.2 - Prob. 7BYGOCh. 1.2 - Prob. 8BYGO
Ch. 1.2 - Prob. 9BYGOCh. 1.3 - Anwer the following questions to test your...Ch. 1.3 - Anwer the following questions to test your...Ch. 1.3 - Prob. 12BYGOCh. 1.3 - Prob. 13BYGOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.1.2AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.2AYLOCh. 1 - Prob. 1.2.3AYLOCh. 1 - Prob. 1.2.4AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.6AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.9AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.11AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.13AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.2.16AYLOCh. 1 - Prob. 1.2.17AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.3.2AYLOCh. 1 - To test your knowledge, discuss the following...Ch. 1 - Prob. 1.3.4AYLOCh. 1 - Prob. 1.3.5AYLOCh. 1 - Prob. 1.3.6AYLOCh. 1 - Prob. 1.3.7AYLOCh. 1 - Structure that can be observed with the naked eye...Ch. 1 - Prob. 2TYRCh. 1 - Prob. 3TYRCh. 1 - Prob. 4TYRCh. 1 - Prob. 5TYRCh. 1 - Which of these regions is not part of the upper...Ch. 1 - Prob. 7TYRCh. 1 - Which of these is not an organ sytem? muscular...Ch. 1 - Prob. 9TYRCh. 1 - An imaging technique that exposes the patient to...Ch. 1 - Prob. 11TYRCh. 1 - The forearm is said to be ________ when the palms...Ch. 1 - Prob. 13TYRCh. 1 - Prob. 14TYRCh. 1 - Prob. 15TYRCh. 1 - Prob. 16TYRCh. 1 - Prob. 17TYRCh. 1 - Prob. 18TYRCh. 1 - Prob. 19TYRCh. 1 - Prob. 20TYRCh. 1 - Prob. 1BYMVCh. 1 - State a meaning of each word element and give a...Ch. 1 - Prob. 3BYMVCh. 1 - Prob. 4BYMVCh. 1 - Prob. 5BYMVCh. 1 - Prob. 6BYMVCh. 1 - Prob. 7BYMVCh. 1 - Prob. 8BYMVCh. 1 - Prob. 9BYMVCh. 1 - Prob. 10BYMVCh. 1 - Prob. 1WWWTSCh. 1 - Prob. 2WWWTSCh. 1 - Briefly explain why each of the following...Ch. 1 - Prob. 4WWWTSCh. 1 - Prob. 5WWWTSCh. 1 - Prob. 6WWWTSCh. 1 - Briefly explain why each of the following...Ch. 1 - Prob. 8WWWTSCh. 1 - Prob. 9WWWTSCh. 1 - Prob. 10WWWTSCh. 1 - Classify each of the following radiologic...Ch. 1 - Prob. 2TYCCh. 1 - Prob. 3TYCCh. 1 - Prob. 4TYCCh. 1 - Why do you think the writers of Terminologia...
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