EBK BIOLOGY
5th Edition
ISBN: 9780133954425
Author: Maier
Publisher: YUZU
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Chapter 11, Problem 3LTB
Summary Introduction
To describe:
The evolution of the Mycobacterium Tuberculosis after the exposure to antibiotics.
Introduction:
TB or Tuberculosis is a condition, in which bacteria infect a part of body. The main cause of the infection is the invasion of the bacterium Mycobacterium Tuberculosis. The bacteria generally infect the lungs and causes its fibrosis.
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Drug-resistant TB can be acquired via sequential mutations in the pathogen’s genome, or via transmission of a resistant pathogen from another person. How can these events be distinguished? Why is it important to know which is more prevalent?
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Discuss why it is important for us to conduct research at the basic level of physiology in order to better understand what makes Mycobacteria latent or grow during an infection so that we can design new and/or better treatment modalities.
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- Although Lilly's project was focused on understanding the prevalence of resistance strains of M. tuberculosis in indigenous populations, she also knew that many patients infected with TB do not have an active disease, ie that the bacteria is latent in the infected lungs. M. tuberculosis is transmitted indirectly via air droplets that are inhaled in the large and small airways. In fact, although 30% of individuals exposed to the bacteria will develop an infection, only 5-10% will develop clinical manifestations. This means 20-25% of people exposed to the bacteria will have a latent disease. Although people with latent disease are not infectious and will not transmit the disease to other community members, latent disease is difficult to diagnose. This was really playing on Lilly's mind, thinking about the difficulty of controlling the spread of the bacteria when most infected people were asymptomatic for years and then suddenly developed active disease, which could then spread for weeks…arrow_forwardShow the process of Mycobacterium tuberculosis in a diagram.arrow_forwardCompare Clostridium botulinum and Mycobacterium tuberculosis to how the pathogens may be similar and differentarrow_forward
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