Biology: The Dynamic Science (MindTap Course List)
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN: 9781305389892
Author: Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher: Cengage Learning
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Chapter 11, Problem 14TYK
Summary Introduction

To review:

The experimental design to determine the adverse effect of a new pesticide launched in the market on egg production and fertilization in frogs.

Introduction:

The chemical contamination of soil and water may acts as a major factor in amphibian population decline. The effects of organic and inorganic chemical contamination on amphibians like frogs may also depend on other biotic and abiotic variables at the time of exposure like UV-radiation. The pesticide endosulfan is an organochlorine cyclodiene which is extensively used in the world. The oxidation product, endosulphan sulphate is frequently transported into riverine environments. Frog embryos and larvae generally develop under the heterogeneous environments, and the concentration of different chemicals affects the various life cycle stages.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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