CAMPBELL BIOLOGY IN FOCUS-W/MASTR.BIO.
3rd Edition
ISBN: 9780134875040
Author: Urry
Publisher: PEARSON
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Chapter 11, Problem 11TYU
In tigers, a recessive allele that is pleiotropic causes an absence of fur pigmentation (a white tiger) and a cross-eyed condition. If two
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 11 Solutions
CAMPBELL BIOLOGY IN FOCUS-W/MASTR.BIO.
Ch. 11.1 - DRAW IT Pea plants heterozygous for flower...Ch. 11.1 - List all gametes that could be made by a pea plant...Ch. 11.1 - Prob. 3CCCh. 11.2 - For any gene with a dominant allele A and...Ch. 11.2 - Two organisms, with genotypes BbDD and BBDd, are...Ch. 11.2 - Prob. 3CCCh. 11.3 - Incomplete dominance and epistasis are both terms...Ch. 11.3 - Prob. 2CCCh. 11.3 - WHAT IF? A rooster with gray feathers and a hen of...Ch. 11.4 - Lucia and Jared each have a sibling with cystic...
Ch. 11.4 - MAKE CONNECTIONS In Table 11.1, note the...Ch. 11 - DRAW IT Two pea plants heterozygous for the...Ch. 11 - A man with type A blood marries a woman with type...Ch. 11 - A man has six fingers on each hand and six toes on...Ch. 11 - Prob. 4TYUCh. 11 - Flower position, stem length, and seed shape are...Ch. 11 - Prob. 6TYUCh. 11 - Prob. 7TYUCh. 11 - Prob. 8TYUCh. 11 - Prob. 9TYUCh. 11 - Prob. 10TYUCh. 11 - In tigers, a recessive allele that is pleiotropic...Ch. 11 - Prob. 12TYUCh. 11 - Prob. 13TYUCh. 11 - Imagine that you are a genetic counselor, and a...Ch. 11 - Prob. 15TYUCh. 11 - Prob. 16TYUCh. 11 - Prob. 17TYUCh. 11 - Prob. 18TYU
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