Principles of Biology
2nd Edition
ISBN: 9781259875120
Author: Robert Brooker, Eric P. Widmaier Dr., Linda Graham Dr. Ph.D., Peter Stiling Dr. Ph.D.
Publisher: McGraw-Hill Education
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Chapter 10.5, Problem 1BC
Summary Introduction
To analyze:
ATP role in tRNA charging.
Introduction:
Amino acid activation is known as aminoacylation or tRNA charging. This process is carried out in two steps: In first the first step ATP is transferred to amino acid and in second step amino acid is joined to its cognate tRNA.
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Name the enzyme responsible for binding of aminoacid to trna?
The charging of a tRNA with an amino acid can be represented by the following equation:amino acid + tRNA + ATP → aminoacyl-tRNA + AMP + PPI where PPI is pyrophosphate (see figure 3–40). in the aminoacyl-tRNA, the amino acid and tRNA are linked with a high-energy covalent bond; a large portion of the energy derived from the hydrolysis of ATP is thus stored in this bond and is available to drive peptide bond formation at the later stages of protein synthesis. the free-energy change of the charging reaction shown in the equation is close to zero and therefore would not be expected to favor attachment of the amino acid to tRNA. Can you suggest a further step that could drive the reaction to completion?
What is the role of ATP(CTP): tRNA nucleotidyletransferase?
Chapter 10 Solutions
Principles of Biology
Ch. 10.1 - What is the direction of flow of genetic...Ch. 10.1 - Prob. 1TYKCh. 10.1 - Prob. 2TYKCh. 10.1 - Prob. 3TYKCh. 10.2 - How would removing a terminator from a gene affect...Ch. 10.2 - Prob. 1BCCh. 10.2 - Prob. 1TYKCh. 10.2 - Prob. 2TYKCh. 10.3 - Do the ends of protein-encoding genes have a poly...Ch. 10.3 - The splicing of pre-mRNA in eukaryotes involves...
Ch. 10.3 - Prob. 2TYKCh. 10.4 - Prob. 1CCCh. 10.4 - Prob. 2CCCh. 10.4 - Prob. 1TYKCh. 10.4 - Prob. 2TYKCh. 10.5 - Prob. 1CCCh. 10.5 - Prob. 1BCCh. 10.5 - Based on the gene sequences shown here, pick two...Ch. 10.5 - Prob. 1TYKCh. 10.5 - Prob. 2TYKCh. 10.5 - Prob. 3TYKCh. 10.6 - Prob. 1CCCh. 10.6 - Prob. 1TYKCh. 10.6 - Prob. 2TYKCh. 10 - Which of the following best represents the central...Ch. 10 - Prob. 2TYCh. 10 - Prob. 3TYCh. 10 - Prob. 4TYCh. 10 - Prob. 5TYCh. 10 - Prob. 6TYCh. 10 - The legion of a tRNA that is complementary to a...Ch. 10 - Prob. 8TYCh. 10 - Prob. 9TYCh. 10 - Prob. 10TYCh. 10 - Lets suppose a gene mutation changed the sixth...Ch. 10 - What is the function of an aminoacyl-tRNA...Ch. 10 - A principle of biology is that the genetic...Ch. 10 - Prob. 1CBQCh. 10 - Prob. 2CBQ
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- The covalent attachment of an amino acid to a tRNA is an endergonic reaction. In other words, it requires an input of energy for the reaction to proceed. Where does the energy come from to attach amino acids to tRNA molecules?arrow_forwardHow does the aminoacyl-tRNA synthetase that attaches the amino acid proline know which tRNA to attach the proline to?Question 24 options: A) the synthetase recognizes the sequence of the first 3 bases on the 3' end of the tRNA B) the synthetase reads the anticodon as well as a few other unique bases in tRNAPro C) proline only fits into the 3-dimensional structure of the tRNAPro D) the synthetase randomly chooses a tRNAarrow_forwardLook back at Figure 6.3, which describes the hydrolysis of ATP. Why is ATP needed to charge a tRNA?arrow_forward
- Why must tRNA molecules have both unique structural features and common structural features?arrow_forwardIn the tertiary structure of tRNA, where is the anticodon region relative to the attachment site for the amino acid? Are these located adjacent to each other?arrow_forwardEach tRNA has unique identity elements recognized by its specific enzyme involved in charging it with the correct amino acid. Is this true or false?arrow_forward
- What enzyme catalyzes protein synthesis in bacteria? You discover a new broad-spectrum antibiotic that inhibits protein synthesis and named it Compound J. You want to determine the mechanism of action of Compound J. After treating bacteria cells with Compound J, you observe many ribosomes with long polypeptide chains bound to them. Based on this observation, make a hypothesis about which part of the ribosome Compound J is binding and how this specifically affects translation. What evidence supports that proper protein folding is essential to all domains of life? Name and describe the function/s of two specific molecules that help proteins fold in bacteria.arrow_forwardThe figure below shows the stage in translation when an incoming aminoacyl-tRNA has bound to the A site on the ribosome. Using the components shown in Figure part A as a guide, explain in detail what happens in the next two stages to complete the addition of a new amino acid to the growing polypeptide chain. Use the E, P, and A sites in your explanation as well as the small and large ribosomal subunits. (A) STEP 1 H2N- E 5' 13' (B) STEP 2 E P A 13' (C) STEP 3arrow_forwardThe synthesis of a protein requires that the amino acids that constitute the growing polypeptide chain be covalently linked to the amino acid attached to the tRNA at the aminoacyl site of the ribosome. Which of the following catalyses this reaction? Options: the aminoacyl tRNA synthetase eEF2 eEF1-GTP a large ribosomal RNA the initiator tRNA metarrow_forward
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