Biology: Concepts and Investigations
4th Edition
ISBN: 9780078024207
Author: Mariëlle Hoefnagels Dr.
Publisher: McGraw-Hill Education
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Chapter 10.2, Problem 3MC
Summary Introduction
To create:
A flow chart with connections between the terms P generation, F1 generation, and F2 generation.
Concept introduction:
Mendel began with the pure-breeding pea plants because the offspring always produced progeny with the same characteristics as that of the parent plant. Mendel cross-breed these peas plants and recorded the
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Outline a method for using apomixis to maintain feminized CannabisAssume apomixis is controlled by a single dominant gene. You can choose the type of apomixis: obligate or facultative, gametophytic or sporophytic. Discuss advantages and disadvantages of your proposed method.
Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 10 Solutions
Biology: Concepts and Investigations
Ch. 10.1 - Describe the relationships among chromosomes, DNA,...Ch. 10.1 - Prob. 2MCCh. 10.2 - Why did Gregor Mendel choose pea plants as his...Ch. 10.2 - Distinguish between dominant and recessive;...Ch. 10.2 - Prob. 3MCCh. 10.3 - What is a monohybrid cross, and what are the...Ch. 10.3 - How are Punnett squares helpful in following...Ch. 10.3 - Prob. 3MCCh. 10.3 - How does the law of segregation reflect the events...Ch. 10.4 - Prob. 1MC
Ch. 10.4 - Prob. 2MCCh. 10.4 - How can the product rule be used to predict the...Ch. 10.5 - How do patterns of inheritance differ for unlinked...Ch. 10.5 - What is the difference between recombinant and...Ch. 10.5 - Prob. 3MCCh. 10.6 - Prob. 1MCCh. 10.6 - Differentiate between pleiotropy and epistasis.Ch. 10.6 - How can the same phenotype stem from many...Ch. 10.6 - Figures 10.18 and 10.20 show two ways that a...Ch. 10.7 - Prob. 1MCCh. 10.7 - Prob. 2MCCh. 10.7 - Why do males and females express recessive...Ch. 10.7 - Prob. 4MCCh. 10.8 - How are pedigrees helpful in determining a...Ch. 10.8 - Prob. 2MCCh. 10.9 - Prob. 1MCCh. 10.9 - What is polygenic inheritance, and how is it...Ch. 10.10 - Prob. 1MCCh. 10.10 - Prob. 2MCCh. 10 - In the list of four terms below, which term is the...Ch. 10 - According to Mendel, if an individual is...Ch. 10 - Prob. 3MCQCh. 10 - Each letter below represents an allele. Which of...Ch. 10 - Which of the following is a possible gamete for an...Ch. 10 - Use the product rule to determine the chance of...Ch. 10 - Refer to the linkage map in figure 10.16b. A...Ch. 10 - How can epistasis decrease the number of...Ch. 10 - Prob. 9MCQCh. 10 - Prob. 10MCQCh. 10 - Prob. 1WIOCh. 10 - Prob. 2WIOCh. 10 - Some people compare a homologous pair of...Ch. 10 - How did Mendel use evidence from monohybrid and...Ch. 10 - Prob. 5WIOCh. 10 - Prob. 6WIOCh. 10 - Prob. 7WIOCh. 10 - Prob. 8WIOCh. 10 - Prob. 9WIOCh. 10 - A family has an X-linked dominant form of...Ch. 10 - X inactivation explains the large color patches in...Ch. 10 - Prob. 12WIOCh. 10 - Prob. 13WIOCh. 10 - Prob. 14WIOCh. 10 - Design an experiment using twins to determine the...Ch. 10 - Prob. 1GPCh. 10 - In Mexican hairless dogs, a dominant allele...Ch. 10 - A species of ornamental fish comes in two colors;...Ch. 10 - Two lizards have green skin and large dewlaps...Ch. 10 - Prob. 5GPCh. 10 - Prob. 6GPCh. 10 - Prob. 7GPCh. 10 - Prob. 8GPCh. 10 - Prob. 1PITCh. 10 - Explain the effects of a mutation, using allele,...Ch. 10 - 3. Add meiosis, gametes, incomplete dominance,...
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