Laboratory Manual for Anatomy and Physiology, 6e WileyPLUS (next generation) + Loose-leaf
6th Edition
ISBN: 9781119490906
Author: Connie Allen, Valerie Harper
Publisher: Wiley (WileyPLUS Products)
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Chapter 10, Problem 6PGP
Summary Introduction
Introduction: The pelvic girdle is composed of two hip bones known as ossa coxae. The lower limb is attached to the axial skeleton by the ossa coxae. The fusion of three separate bones called ischium, ilium, and pubis bones forms each os coxa. In children, these three bones are recognizable as separate bones.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 10 Solutions
Laboratory Manual for Anatomy and Physiology, 6e WileyPLUS (next generation) + Loose-leaf
Ch. 10 - Prob. 1.1BGLCh. 10 - Label the parts of the humerus in Figure 10.3(a)...Ch. 10 - Label the bones of the hand in Figure 10.5. For...Ch. 10 - Label the bones and bone markings of an os coxa in...Ch. 10 - Label the bones and bone markings of the pelvis in...Ch. 10 - Label the bones and bone markings of the femur in...Ch. 10 - Label Figure 10.10(a) and (b). For each phalanx,...Ch. 10 - __________ The acromion (process) articulates with...Ch. 10 - _____ Is the clavicle anterior or posterior...Ch. 10 - ______________________ The clavicle articulates...
Ch. 10 - ______________________ The humerus articulates...Ch. 10 - Prob. 5PGCh. 10 - __________ Name the two bones that make up the...Ch. 10 - __________ What part of the radius articulates...Ch. 10 - __________ What part of the ulna fits into the...Ch. 10 - ______________________ The coronoid process...Ch. 10 - __________ Is the ulna medial or lateral compared...Ch. 10 - __________ What are the bones called that make up...Ch. 10 - __________ What are the bones called that make up...Ch. 10 - __________ What is the name of the lateral condyle...Ch. 10 - __________ What is the name of the medial condyle...Ch. 10 - __________ What is the name of the slender,...Ch. 10 - ______________________ What is the name of the...Ch. 10 - ______________________ When you put your hands on...Ch. 10 - ______________________ With your hands on your...Ch. 10 - ______________________ Name the 2 bones that form...Ch. 10 - ______________________ What prominent bone marking...Ch. 10 - ______________________ Name the bones of the ossa...Ch. 10 - ______________________ The female pelvis has...Ch. 10 - ______________________ Name the anterior joint...Ch. 10 - Prob. 8PGPCh. 10 - ______________________ Largest foramen in the...Ch. 10 - ______________________ The pelvic outlet is larger...Ch. 10 - ______________________ Is the fibula medial or...Ch. 10 - ______________________ What is the correct term...Ch. 10 - ______________________ What is the heaviest and...Ch. 10 - ______________________ Name the thigh bone.
Ch. 10 - ______________________ The fibula is a...Ch. 10 - ______________________ Name the tarsal bone that...Ch. 10 - ______________________ Name the heel bone.
Ch. 10 - ______________________ Name the bones of the foot...Ch. 10 - ______________________ Bone marking that is...Ch. 10 - ______________________ Bone that is commonly...Ch. 10 - ______________________ Processes on the femur and...Ch. 10 - _____ Name of the bone marking of the femur that...Ch. 10 - ______________________ Does the fibula form part...Ch. 10 - ______________________ Name the phalanges in the...Ch. 10 - _____ The number of metatarsal bones.
Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - Identify the bones and bone markings in Figure...Ch. 10 - __________ (bone marking)
Ch. 10 - Prob. 2UYKCh. 10 - __________ (bone marking)
Ch. 10 - __________ (bone)
Ch. 10 - Prob. 5UYKCh. 10 - Prob. 6UYKCh. 10 - Prob. 7UYKCh. 10 - Prob. 8UYKCh. 10 - Prob. 9UYKCh. 10 - Prob. 10UYKCh. 10 - Prob. 11UYKCh. 10 - Prob. 12UYKCh. 10 - _______________ Name the bone the ring is on.
Ch. 10 - Prob. 14UYKCh. 10 - ____________________ (bone marking)
Ch. 10 - Prob. 16UYKCh. 10 - Prob. 17UYKCh. 10 - Prob. 18UYKCh. 10 - Prob. 19UYKCh. 10 - ____________________ (bone marking)
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