Human Anatomy & Physiology Plus Modified Mastering A&P with Pearson eText -- Access Card Package 11th edition
11th Edition
ISBN: 9780135175040
Author: Marieb
Publisher: PEARSON
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Textbook Question
Chapter 10, Problem 5CCS
45-Year-Old Female with Motor Nerve Damage
In Chapters 7 and 8, you met Kayla Tanner, who suffered a dislocated right hip in a car accident. Six weeks later, Mrs. Tanner was still unable to walk or run without hip pain, and had weakness in flexion at the knee, excessive foot inversion and plantar flexion, and significant “foot drop” (the inability to dorsiflex the foot).
Electromyography (measurement of muscle electrical activity) and nerve conduction studies (measurement of the speed of nerve impulses) revealed sciatic nerve damage, most likely a result of the nerve being compressed when the hip was dislocated. This large nerve innervates many lower limb muscles. Since her surgery, Mrs. Tanner has been undergoing intense physical therapy and has shown significant improvement.
5. Using descriptions similar to those listed in the question above, explain how you would assess the function of the following muscles:
a. Extensor hallucislongus
b. Fibularis (peroneus) longus
c. Gastrocnemius
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 10 Solutions
Human Anatomy & Physiology Plus Modified Mastering A&P with Pearson eText -- Access Card Package 11th edition
Ch. 10 - Prob. 1RQCh. 10 - 2. The arrangement of muscle fibers in which the...Ch. 10 - 3. Match the muscle names in column B to the...Ch. 10 - 4. The prime mover of inspiration is the (a)...Ch. 10 - 5. The arm muscle that both flexes the elbow and...Ch. 10 - 6. The chewing muscles that protract the mandible...Ch. 10 - 7. Muscles that depress the hyoid bone and larynx...Ch. 10 - 8. Intrinsic muscles of the back that promote...Ch. 10 - Prob. 9RQCh. 10 - Aprime mover of thigh flexion is the (a)rectus...
Ch. 10 - The prime mover of thigh extension against...Ch. 10 - Prob. 12RQCh. 10 - Prob. 13RQCh. 10 - 17. Name four criteria used in naming muscles, and...Ch. 10 - 18. Differentiate between the arrangement of...Ch. 10 - 20. Which muscles act to propel food down the...Ch. 10 - Prob. 15RQCh. 10 - Prob. 19RQCh. 10 - Prob. 20RQCh. 10 - As Kendra's coach watched her sail over the high...Ch. 10 - 24. (a) Name two forearm muscles that are powerful...Ch. 10 - Prob. 21RQCh. 10 - Prob. 24RQCh. 10 - Prob. 22RQCh. 10 - 3. Mr. Ahmadi, an out-of-shape 45-year-old man,...Ch. 10 - What class of lever system do the following...Ch. 10 - 45-Year-Old Female with Motor Nerve Damage
In...Ch. 10 - 45-Year-Old Female with Motor Nerve Damage
In...Ch. 10 - 45-Year-Old Female with Motor Nerve Damage In...Ch. 10 - 45-Year-Old Female with Motor Nerve Damage In...Ch. 10 - 45-Year-Old Female with Motor Nerve Damage In...Ch. 10 - 45-Year-Old Female with Motor Nerve Damage
In...
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