Hole's Human Anatomy & Physiology
15th Edition
ISBN: 9781259864568
Author: SHIER, David, Butler, Jackie, Lewis, Ricki
Publisher: Mcgraw-hill Education,
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Chapter 10, Problem 4IA
Summary Introduction
To determine:
A neurotransmitter imbalance that lies behind Alzheimer disease. Based on the information that the drugs that improve early symptoms of Alzheimer disease do so by slowing the breakdown of acetylcholine in synaptic clefts in certain parts of the brain.
Introduction:
Synaptic transmission is a process of neuron communication. The two neurons are physically separated from each other by a synaptic cleft or gap. The process of synaptic transmission is carried out by neurotransmitters which are a chemical released from the synaptic end of a neuron.
A neurotransmitter helps in the passing of information in the form of nerve impulses. It is a one-way process that carries the information as nerve impulses from presynaptic axon to the terminal of the axon.
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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.
b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake?
Options:
A. Dose; Increase dose
B. Dose; Decrease dose
C. Dose; Do not change dose
D. Interval; Increase the interval between doses (give the drug less frequently)
E. Interval; Decrease the interval between doses (give the drug more frequently)
F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
Chapter 10 Solutions
Hole's Human Anatomy & Physiology
Ch. 10 - Prob. 1PCh. 10 - Name two groups of nervous system organs.Ch. 10 - Prob. 3PCh. 10 - Prob. 4PCh. 10 - Prob. 5PCh. 10 - 6 Describe the types of neurons based on...Ch. 10 - Prob. 7PCh. 10 - 8 Name and describe four types of neuroglia.
Ch. 10 - What are some functions of neuroglia?Ch. 10 - Prob. 10P
Ch. 10 - Prob. 11PCh. 10 - Prob. 12PCh. 10 - Prob. 13PCh. 10 - Prob. 14PCh. 10 - Prob. 15PCh. 10 - 16 Explain how impulse conduction differs in...Ch. 10 - Prob. 17PCh. 10 - Prob. 18PCh. 10 - Prob. 19PCh. 10 - Prob. 20PCh. 10 - What is a neuronal pool?Ch. 10 - Define facilitation.Ch. 10 - Prob. 23PCh. 10 - What is divergence?Ch. 10 - Prob. 1CACh. 10 - Prob. 2CACh. 10 - Prob. 3CACh. 10 - Prob. 4CACh. 10 - Prob. 5CACh. 10 - Prob. 6CACh. 10 - Prob. 7CACh. 10 - Prob. 8CACh. 10 - Prob. 9CACh. 10 - Prob. 10CACh. 10 - Prob. 11CACh. 10 - Prob. 12CACh. 10 - Prob. 13CACh. 10 - Prob. 14CACh. 10 - Prob. 15CACh. 10 - 16 Explain how malfunctioning neuroglia can harm...Ch. 10 - Prob. 17CACh. 10 - Prob. 18CACh. 10 - Prob. 19CACh. 10 - Explain how information is passed from a...Ch. 10 - Prob. 21CACh. 10 - Prob. 22CACh. 10 - Distinguish among polarized, hyperpolarized, and...Ch. 10 - Prob. 24CACh. 10 - Prob. 25CACh. 10 - Prob. 26CACh. 10 - Prob. 27CACh. 10 - Prob. 28CACh. 10 - Prob. 29CACh. 10 - Explain how enzymes within synaptic clefts and...Ch. 10 - Prob. 31CACh. 10 - Prob. 32CACh. 10 - Prob. 33CACh. 10 - Why are rapidly growing cancers that originate in...Ch. 10 - In Tay-Sachs disease, an infant rapidly loses...Ch. 10 - How would you explain the following observations?...Ch. 10 - Prob. 4IACh. 10 - Prob. 5IA
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